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Is VEGF a key target of cotinine and other potential therapies against Alzheimer disease?

dc.contributor.authorEcheverria V.
dc.contributor.authorBarreto G.E.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorTarasov V.V.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:17:28Z
dc.date.available2020-09-02T22:17:28Z
dc.date.issued2017
dc.identifier10.2174/1567205014666170329113007
dc.identifier.citation14, 11, 1155-1163
dc.identifier.issn15672050
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4448
dc.descriptionBackground: The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been shown that environmental enrichment and exercise, two non-pharmacological interventions that are beneficial decreasing the progression of Alzheimer disease (AD) and depressive-like behavior, enhance hippocampal VEGF expression and neurogenesis. Furthermore, the stimulation of VEGF expression promotes neurotransmission and synaptic plasticity processes such as neurogenesis. It is thought that these VEGF actions in the brain, may underly its beneficial therapeutic effects against psychiatric and other neurological conditions. Conclusion: In this review, evidence linking VEGF deficit with the development of AD as well as the potential role of VEGF signaling as a therapeutic target for cotinine and other interventions in neurodegenerative conditions are discussed. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAlzheimer disease
dc.subjectAmyotrophic lateral sclerosis
dc.subjectAngiogenesis
dc.subjectCotinine
dc.subjectDementia
dc.subjectDepression
dc.subjectNeurodegeneration
dc.subjectNicotinic receptors
dc.subjectTobacco
dc.subjectVEGF
dc.subjectcotinine
dc.subjectneuroprotective agent
dc.subjectvasculotropin A
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjecthuman
dc.subjectmetabolism
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectCotinine
dc.subjectHumans
dc.subjectNeuroprotective Agents
dc.subjectVascular Endothelial Growth Factor A
dc.titleIs VEGF a key target of cotinine and other potential therapies against Alzheimer disease?
dc.typeReview


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