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Expression of Toll-like receptors 2 and 4 and its association with matrix metalloproteinases in symptomatic and asymptomatic apical periodontitis

dc.contributor.authorFernández A.
dc.contributor.authorCárdenas A.M.
dc.contributor.authorAstorga J.
dc.contributor.authorVeloso P.
dc.contributor.authorAlvarado A.
dc.contributor.authorMerino P.
dc.contributor.authorPino D.
dc.contributor.authorReyes-Court D.
dc.contributor.authorHernández M.
dc.date.accessioned2020-09-02T22:17:26Z
dc.date.available2020-09-02T22:17:26Z
dc.date.issued2019
dc.identifier10.1007/s00784-019-02861-9
dc.identifier.citation23, 12, 4205-4212
dc.identifier.issn14326981
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4439
dc.descriptionTo determine Toll-like receptors (TLR)2 and TLR4 expression levels and associate them with matrix metalloproteinases (MMPs) in asymptomatic apical periodontitis (AAP), symptomatic apical periodontitis (SAP), and healthy controls. Apical tissue/lesion samples were obtained from chronic AAP (n = 35) and SAP (n = 29), and healthy periodontal ligament (HPL, n = 10) with indication of tooth extraction, respectively. mRNA expression levels of TLR2, TLR4, MMP-1, MMP-2, MMP-8, and MMP-13 were determined by real-time reverse-transcription polymerase chain reaction. The data were analyzed with Kruskal-Wallis and Dunn’s pot hoc test (p < 0.05). The correlation coefficient was obtained using the Spearman correlation (p < 0.05). TLR2, MMP-1, MMP-2, and MMP-13 mRNA levels were the highest in SAP followed by AAP and controls (p < 0.05). TLR4 and MMP-8 were over expressed in AAP and SAP compared to HPL (p < 0.05). TLR2 positively correlated with TLR4, MMP-1, MMP-8, and MMP-13 in SAP (p < 0.05). TLR2 and TLR4 are overexpressed in apical lesions versus healthy periodontal ligament and correlate with collagenolytic MMPs. Particularly, TLR2 is overexpressed in SAP in association with MMP-1, MMP-8, and MMP-13. Our results suggest that the activation of TLR2 along with MMP overexpression might contribute to SAP clinical presentation and progression. TLRs, MMPs, and their interaction can explain the clinical presentations and evolution of apical periodontitis and might represent key targets for new diagnostic and treatment approaches. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subjectMatrix metalloproteinases
dc.subjectPeriapical periodontitis
dc.subjectToll-like receptor 2
dc.subjectToll-like receptor 4
dc.subjectmatrix metalloproteinase
dc.subjecttoll like receptor 2
dc.subjecttoll like receptor 4
dc.subjectcross-sectional study
dc.subjectdrug effect
dc.subjectgenetics
dc.subjecthuman
dc.subjectmetabolism
dc.subjectpathology
dc.subjectperiodontal ligament
dc.subjecttooth apex
dc.subjecttooth periapical disease
dc.subjectCross-Sectional Studies
dc.subjectHumans
dc.subjectMatrix Metalloproteinases
dc.subjectPeriapical Periodontitis
dc.subjectPeriodontal Ligament
dc.subjectToll-Like Receptor 2
dc.subjectToll-Like Receptor 4
dc.subjectTooth Apex
dc.titleExpression of Toll-like receptors 2 and 4 and its association with matrix metalloproteinases in symptomatic and asymptomatic apical periodontitis
dc.typeArticle


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