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TiO2-nanowired delivery of DL-3-n-butylphthalide (DL-NBP) attenuates blood-brain barrier disruption, brain edema formation, and neuronal damages following concussive head injury

dc.contributor.authorFeng L.
dc.contributor.authorSharma A.
dc.contributor.authorNiu F.
dc.contributor.authorHuang Y.
dc.contributor.authorLafuente J.V.
dc.contributor.authorMuresanu D.F.
dc.contributor.authorOzkizilcik A.
dc.contributor.authorTian Z.R.
dc.contributor.authorSharma H.S.
dc.date.accessioned2020-09-02T22:17:25Z
dc.date.available2020-09-02T22:17:25Z
dc.date.issued2018
dc.identifier10.1007/s12035-017-0746-5
dc.identifier.citation55, 1, 350-358
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4434
dc.descriptionDL-3-n-butylphthalide (DL-NBP) is one of the constituents of Chinese celery extract that is used to treat stroke, dementia, and ischemic diseases. However, its role in traumatic brain injury is less well known. In this investigation, neuroprotective effects of DL-NBP in concussive head injury (CHI) on brain pathology were explored in a rat model. CHI was inflicted in anesthetized rats by dropping a weight of 114.6 g from a height of 20 cm through a guide tube on the exposed right parietal bone inducing an impact of 0.224 N and allowed them to survive 4 to 24 h after the primary insult. DL-NBP was administered (40 or 60 mg/kg, i.p.) 2 and 4 h after injury in 8-h survival group and 8 and 12 h after trauma in 24-h survival group. In addition, TiO2-nanowired delivery of DL-NBP (20 or 40 mg/kg, i.p.) in 8 and 24 h CHI rats was also examined. Untreated CHI showed a progressive increase in blood-brain barrier (BBB) breakdown to Evans blue albumin (EBA) and radioiodine ([131]- I), edema formation, and neuronal injuries. The magnitude and intensity of these pathological changes were most marked in the left hemisphere. Treatment with DL-NBP significantly reduced brain pathology in CHI following 8 to 12 h at 40-mg dose. However, 60-mg dose is needed to thwart brain pathology at 24 h following CHI. On the other hand, TiO2-DL-NBP was effective in reducing brain damage up to 8 or 12 h using a 20-mg dose and only 40-mg dose was needed for neuroprotection in CHI at 24 h. These observations are the first to suggest that (i) DL-NBP is quite effective in reducing brain pathology and (ii) nanodelivery of DL-NBP has far more superior effects in CHI, not reported earlier. © Springer Science+Business Media New York 2016.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectBlood-brain barrier
dc.subjectBrain edema
dc.subjectConcussive head injury (CHI)
dc.subjectDL-3-n-butylphthalide (DL-NBP)
dc.subjectNeuronal injury
dc.subjectNeuroprotection
dc.subjectTiO2 nanodelivery
dc.subjectbutylphthalide
dc.subjectEvans blue
dc.subjectiodine 131
dc.subjectnanowire
dc.subjecttitanium dioxide
dc.subject3-n-butylphthalide
dc.subjectbenzofuran derivative
dc.subjectnanowire
dc.subjectneuroprotective agent
dc.subjecttitanium
dc.subjecttitanium dioxide
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectblood brain barrier
dc.subjectbrain damage
dc.subjectbrain edema
dc.subjectbrain tissue
dc.subjectconcussive head injury
dc.subjectconcussive head injury
dc.subjectcontrolled study
dc.subjectdrug delivery system
dc.subjectdrug efficacy
dc.subjecthead injury
dc.subjecthistopathology
dc.subjectmale
dc.subjectnervous system injury
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectparietal bone
dc.subjectrat
dc.subjectsurvival
dc.subjectanimal
dc.subjectblood brain barrier
dc.subjectbrain concussion
dc.subjectbrain edema
dc.subjectcomplication
dc.subjectdrug delivery system
dc.subjectdrug effect
dc.subjectnerve cell
dc.subjectpathology
dc.subjectprocedures
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectBenzofurans
dc.subjectBlood-Brain Barrier
dc.subjectBrain Concussion
dc.subjectBrain Edema
dc.subjectDrug Delivery Systems
dc.subjectMale
dc.subjectNanowires
dc.subjectNeurons
dc.subjectNeuroprotective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTitanium
dc.titleTiO2-nanowired delivery of DL-3-n-butylphthalide (DL-NBP) attenuates blood-brain barrier disruption, brain edema formation, and neuronal damages following concussive head injury
dc.typeArticle


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