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The development of human digital Meissner's and Pacinian corpuscles

dc.contributor.authorFeito J.
dc.contributor.authorGarcía-Suárez O.
dc.contributor.authorGarcía-Piqueras J.
dc.contributor.authorGarcía-Mesa Y.
dc.contributor.authorPérez-Sánchez A.
dc.contributor.authorSuazo I.
dc.contributor.authorCabo R.
dc.contributor.authorSuárez-Quintanilla J.
dc.contributor.authorCobo J.
dc.contributor.authorVega J.A.
dc.date.accessioned2020-09-02T22:17:25Z
dc.date.available2020-09-02T22:17:25Z
dc.date.issued2018
dc.identifier10.1016/j.aanat.2018.05.001
dc.identifier.citation219, , 8-24
dc.identifier.issn09409602
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4432
dc.descriptionMeissner's and Pacinian corpuscles are cutaneous mechanoreceptors responsible for different modalities of touch. The development of these sensory formations in humans is poorly known, especially regarding the acquisition of the typical immunohistochemical profile related to their full functional maturity. Here we used a panel of antibodies (to specifically label the main corpuscular components: axon, Schwann-related cells and endoneurial-perineurial-related cells) to investigate the development of digital Meissner's and Pacinian corpuscles in a representative sample covering from 11 weeks of estimated gestational age (wega) to adulthood. Development of Pacinian corpuscles starts at 13 wega, and it is completed at 4 months of life, although their basic structure and immunohistochemical characteristics are reached at 36 wega. During development, around the axon, a complex network of S100 positive Schwann-related processes is progressively compacted to form the inner core, while the surrounding mesenchyme is organized and forms the outer core and the capsule. Meissner's corpuscles start to develop at 22 wega and complete their typical morphology and immunohistochemical profile at 8 months of life. In developing Meissner's corpuscles, the axons establish complex relationships with the epidermis and are progressively covered by Schwann-like cells until they complete the mature arrangement late in postnatal life. The present results demonstrate an asynchronous development of the Meissner's and Pacini's corpuscles and show that there is not a total correlation between morphological and immunohistochemical maturation. The correlation of the present results with touch-induced cortical activity in developing humans is discussed. © 2018 Elsevier GmbH
dc.language.isoen
dc.publisherElsevier GmbH
dc.subjectDevelopment
dc.subjectGlabrous skin
dc.subjectHuman
dc.subjectMeissner's corpuscles
dc.subjectPacinian corpuscles
dc.subjectSensory corpuscles
dc.subjectadult
dc.subjectadulthood
dc.subjectarticle
dc.subjectaxon
dc.subjectendoneurium
dc.subjectepidermis
dc.subjectgestational age
dc.subjectglabrous skin
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectmaturation
dc.subjectmesenchyme
dc.subjectmorphology
dc.subjectPacini corpuscle
dc.subjecttouch
dc.subjectadolescent
dc.subjectaged
dc.subjectanatomy and histology
dc.subjectanimal
dc.subjectcytology
dc.subjectembryology
dc.subjectfemale
dc.subjectfinger
dc.subjectfluorescent antibody technique
dc.subjectgrowth, development and aging
dc.subjectimmunology
dc.subjectinfant
dc.subjectLeporidae
dc.subjectmale
dc.subjectmechanoreceptor
dc.subjectmiddle aged
dc.subjectmouse
dc.subjectnewborn
dc.subjectPacini corpuscle
dc.subjectphysiology
dc.subjectpregnancy
dc.subjectskin
dc.subjectantibody
dc.subjectcollagen type 4
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnimals
dc.subjectAntibodies
dc.subjectAxons
dc.subjectCollagen Type IV
dc.subjectFemale
dc.subjectFingers
dc.subjectFluorescent Antibody Technique
dc.subjectGestational Age
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectMechanoreceptors
dc.subjectMice
dc.subjectMiddle Aged
dc.subjectPacinian Corpuscles
dc.subjectPregnancy
dc.subjectRabbits
dc.subjectSkin
dc.titleThe development of human digital Meissner's and Pacinian corpuscles
dc.typeArticle


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