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An active lifestyle induces positive antioxidant enzyme modulation in peripheral blood mononuclear cells of overweight/obese postmenopausal women

dc.contributor.authorFarinha J.B.
dc.contributor.authorDe Carvalho N.R.
dc.contributor.authorSteckling F.M.
dc.contributor.authorDe Vargas L.D.S.
dc.contributor.authorCourtes A.A.
dc.contributor.authorStefanello S.T.
dc.contributor.authorMartins C.C.
dc.contributor.authorBresciani G.
dc.contributor.authorDos Santos D.L.
dc.contributor.authorSoares F.A.A.
dc.date.accessioned2020-09-02T22:17:23Z
dc.date.available2020-09-02T22:17:23Z
dc.date.issued2015
dc.identifier10.1016/j.lfs.2014.11.022
dc.identifier.citation121, , 152-157
dc.identifier.issn00243205
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4420
dc.descriptionAims: The aim of this study was to investigate the effects of an active lifestyle on mitochondrial functioning, viability, bioenergetics, and redox status markers in peripheral blood mononuclear cells (PBMC) of overweight/ obese postmenopausal women.Materials and methods: We performed a cross-sectional study with postmenopausal women aged 45-64 years and body mass index N 25 kg/m2, divided into physically active (n = 23) and sedentary (n = 12) groups. Mitochondria functioning and viability, bioenergetics and redox status parameters were assessed in PBMC with spectrophotometric and fluorometric assays.Key findings: No differences were found in the enzyme activity of complexes I and II of the electron transport chain (ETC), mitochondrial superoxide dismutase (MnSOD) activity, methyl-tetrazolium reduction levels and reduced glutathione and oxidized glutathione levels between the groups. However, the physically active group presented higher levels of reactive oxygen species (ROS) (P= 0.04) and increased catalase (CAT) (P= 0.029), total (P= 0.011) and cytosolic SOD (CuZnSOD) (P= 0.009) activities.Significance: An active lifestyle that includes aerobic exercise for at least 30 min, three times per week may improve antioxidant enzyme activities in PBMC in overweight/obese postmenopausal women, without changes in the activity of the ETC enzymes. However, this low intensity physical activity is not able to induce relevant mitochondrial adaptations. © 2014 Elsevier Inc. All rights reserved.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectElectron transport chain complex proteins
dc.subjectExercise
dc.subjectLeukocytes
dc.subjectMenopause
dc.subjectObesity
dc.subjectReactive oxygen species
dc.subjectantioxidant
dc.subjectcatalase
dc.subjectcopper zinc superoxide dismutase
dc.subjectglutathione
dc.subjectglutathione disulfide
dc.subjectmanganese superoxide dismutase
dc.subjectreactive oxygen metabolite
dc.subjectreduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone)
dc.subjectsuccinate dehydrogenase (ubiquinone)
dc.subjectantioxidant
dc.subjectcatalase
dc.subjectreactive oxygen metabolite
dc.subjectsuperoxide dismutase
dc.subjectadult
dc.subjectArticle
dc.subjectbioenergy
dc.subjectcell viability
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectfluorometry
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlifestyle
dc.subjectmitochondrion
dc.subjectobesity
dc.subjectoxidation reduction reaction
dc.subjectperipheral blood mononuclear cell
dc.subjectphysical activity
dc.subjectpostmenopause
dc.subjectrespiratory chain
dc.subjectspectrophotometry
dc.subjectcross-sectional study
dc.subjectenergy metabolism
dc.subjectenzymology
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmonocyte
dc.subjectmotor activity
dc.subjectobesity
dc.subjectoxidation reduction reaction
dc.subjectphysiology
dc.subjectpostmenopause
dc.subjectAntioxidants
dc.subjectCatalase
dc.subjectCross-Sectional Studies
dc.subjectEnergy Metabolism
dc.subjectFemale
dc.subjectHumans
dc.subjectLife Style
dc.subjectMiddle Aged
dc.subjectMonocytes
dc.subjectMotor Activity
dc.subjectObesity
dc.subjectOverweight
dc.subjectOxidation-Reduction
dc.subjectPostmenopause
dc.subjectReactive Oxygen Species
dc.subjectSuperoxide Dismutase
dc.titleAn active lifestyle induces positive antioxidant enzyme modulation in peripheral blood mononuclear cells of overweight/obese postmenopausal women
dc.typeArticle


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