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Determination of norepinephrine using a glassy carbon electrode modified with graphene quantum dots and gold nanoparticles by square wave stripping voltammetry

dc.contributor.authorFajardo A.
dc.contributor.authorTapia D.
dc.contributor.authorPizarro J.
dc.contributor.authorSegura R.
dc.contributor.authorJara P.
dc.date.accessioned2020-09-02T22:17:22Z
dc.date.available2020-09-02T22:17:22Z
dc.date.issued2019
dc.identifier10.1007/s10800-019-01288-0
dc.identifier.citation49, 4, 423-432
dc.identifier.issn0021891X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4416
dc.descriptionIn this work, a glassy carbon electrode modified with graphene quantum dots and gold nanoparticles (GCE/GQDs/AuNPs) was developed for norepinephrine (NE) determination using squarewave stripping voltammetry. GQDs were synthesized by citric acid pyrolysis and characterized by UV–Vis and fluorescence spectroscopy. The chemically synthesized AuNPs were characterized by transmission electron microscopy and UV–Vis spectroscopy (Plasmon Band). GCE/GQDs surface was characterized by Raman spectroscopy and scanning electron microscopy. The conditions for the determination of NE with GCE/GQDs/AuNPs were optimized. The linear range was observed between 0.5 and 7.5 µmol L −1 , with a detection limit (LOD) of 0.15 µmol L −1 . The proposed methodology was validated with spiked samples for good precision and accuracy. GCE/GQDs/AuNPs were used in pharmaceutical preparations (NE ampoules) and in rat brain tissue with satisfactory results. Graphical abstract: [Figure not available: see fulltext.]. © 2019, Springer Nature B.V.
dc.language.isoen
dc.publisherSpringer Netherlands
dc.subjectElectrochemical sensor
dc.subjectGold nanoparticles
dc.subjectGraphene quantum dots
dc.subjectNorepinephrine
dc.subjectSquarewave stripping voltammetry
dc.subjectDrug products
dc.subjectElectrochemical sensors
dc.subjectFiber optic sensors
dc.subjectFluorescence spectroscopy
dc.subjectGlass
dc.subjectGold nanoparticles
dc.subjectGraphene
dc.subjectHigh resolution transmission electron microscopy
dc.subjectMetal nanoparticles
dc.subjectNanocrystals
dc.subjectNanometals
dc.subjectNorepinephrine
dc.subjectScanning electron microscopy
dc.subjectSemiconductor quantum dots
dc.subjectVoltammetry
dc.subjectDetection limits
dc.subjectGlassy carbon electrodes
dc.subjectPharmaceutical preparations
dc.subjectPlasmon band
dc.subjectRat brain tissue
dc.subjectSpiked samples
dc.subjectSquare-wave stripping voltammetry
dc.subjectVIS spectroscopy
dc.subjectGlass membrane electrodes
dc.titleDetermination of norepinephrine using a glassy carbon electrode modified with graphene quantum dots and gold nanoparticles by square wave stripping voltammetry
dc.typeArticle


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