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Circulating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment

dc.contributor.authorDíez-Planelles C.
dc.contributor.authorSánchez-Lozano P.
dc.contributor.authorCrespo M.C.
dc.contributor.authorGil-Zamorano J.
dc.contributor.authorRibacoba R.
dc.contributor.authorGonzález N.
dc.contributor.authorSuárez E.
dc.contributor.authorMartínez-Descals A.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorÁlvarez V.
dc.contributor.authorMartín-Hernández R.
dc.contributor.authorHuerta-Ruíz I.
dc.contributor.authorGonzález-García I.
dc.contributor.authorCosgaya J.M.
dc.contributor.authorVisioli F.
dc.contributor.authorDávalos A.
dc.contributor.authorIglesias-Gutiérrez E.
dc.contributor.authorTomás-Zapico C.
dc.date.accessioned2020-09-02T22:17:19Z
dc.date.available2020-09-02T22:17:19Z
dc.date.issued2016
dc.identifier10.1016/j.phrs.2016.05.005
dc.identifier.citation108, , 102-110
dc.identifier.issn10436618
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4393
dc.descriptionHuntington's disease (HD) is a hereditary neurodegenerative disease, with peripheral consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) are being explored for their roles in intercellular communication and gene expression regulation, which allows gaining insight into the regulation of crosstalk between neuronal and peripheral tissues. Here, we explore the cmiRNA profile of plasma samples from fifteen symptomatic patients, with 40-45 CAG repeats in the HTT gene, and seven healthy matched controls. Isolated miRNAs from plasma samples were run against human miRNome panels, which have sequences for 752 human mature miRNAs. We found that 168 cmiRNAs are altered in symptomatic patients. Considering Bonferroni's correction, miR-877-5p, miR-223-3p, miR-223-5p, miR-30d-5p, miR-128, miR-22-5p, miR-222-3p, miR-338-3p, miR-130b-3p, miR-425-5p, miR-628-3p, miR-361-5p, miR-942 are significantly increased in HD patients as compared with controls. Moreover, after patient's organization according to approved HD scales, miR-122-5p is significantly decreased in HD patients with Unified Huntington's Disease Rating Scale >24, whereas an increase in miR-100-5p levels and a decrease in miR-641 and miR-330-3p levels were recorded when patients were rearranged by Total Functional Capacity. These results suggest that cmiRNA profile could be further modified by disease progression, making cmiRNAs useful as monitoring biomarkers. Analysis of target genes indicated a general overexpression of cmiRNAs implicated in metabolism regulation. Profiling cmiRNA of HD subjects opens the possibility of personalized therapies for different groups of HD patients, based on disease modifiers: regulation of altered pathways might contribute to not only alleviate disease symptoms, but also influence HD progression. © 2016 Elsevier Ltd. All rights reserved.
dc.language.isoen
dc.publisherAcademic Press
dc.subjectBiomarker
dc.subjectCirculating microRNA
dc.subjectHuntington's disease
dc.subjectMetabolism
dc.subjectmicroRNA
dc.subjectPlasma
dc.subjectinsulin
dc.subjectleptin
dc.subjectmicroRNA
dc.subjectmicroRNA 128
dc.subjectmicroRNA 130b 3p
dc.subjectmicroRNA 22 5p
dc.subjectmicroRNA 223 3p
dc.subjectmicroRNA 223 5p
dc.subjectmicroRNA 228 3p
dc.subjectmicroRNA 338 3p
dc.subjectmicroRNA 361 5p
dc.subjectmicroRNA 425 5p
dc.subjectmicroRNA 628 3p
dc.subjectmicroRNA 877 5p
dc.subjectmicroRNA 942
dc.subjectreelin
dc.subjectunclassified drug
dc.subjectbiological marker
dc.subjectcirculating microRNA
dc.subjectAATK gene
dc.subjectArticle
dc.subjectcholesterol metabolism
dc.subjectcontrolled study
dc.subjectdisease course
dc.subjectdown regulation
dc.subjectexon
dc.subjectexosome
dc.subjectgene
dc.subjectgene expression profiling
dc.subjectgene overexpression
dc.subjectgene sequence
dc.subjectgene targeting
dc.subjectHIP1 gene
dc.subjectHTT gene
dc.subjecthuman
dc.subjectHuntington chorea
dc.subjectinsulin release
dc.subjectintron
dc.subjectpriority journal
dc.subjectSP1 gene
dc.subjectupregulation
dc.subjectadult
dc.subjectaged
dc.subjectblood
dc.subjectdisease exacerbation
dc.subjectgene expression profiling
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectHuntington chorea
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectquality of life
dc.subjectAdult
dc.subjectAged
dc.subjectBiomarkers
dc.subjectCirculating MicroRNA
dc.subjectDisease Progression
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation
dc.subjectHumans
dc.subjectHuntington Disease
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectQuality of Life
dc.titleCirculating microRNAs in Huntington's disease: Emerging mediators in metabolic impairment
dc.typeArticle


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