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The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity

dc.contributor.authorEscobedo N.
dc.contributor.authorOliver G.
dc.date.accessioned2020-09-02T22:17:17Z
dc.date.available2020-09-02T22:17:17Z
dc.date.issued2017
dc.identifier10.1016/j.cmet.2017.07.020
dc.identifier.citation26, 4, 598-609
dc.identifier.issn15504131
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4384
dc.descriptionObesity is a key risk factor for metabolic and cardiovascular diseases, and although we understand the mechanisms regulating weight and energy balance, the causes of some forms of obesity remain enigmatic. Despite the well-established connections between lymphatics and lipids, and the fact that intestinal lacteals play key roles in dietary fat absorption, the function of the lymphatic vasculature in adipose metabolism has only recently been recognized. It is well established that angiogenesis is tightly associated with the outgrowth of adipose tissue, as expanding adipose tissue requires increased nutrient supply from blood vessels. Results supporting a crosstalk between lymphatic vessels and adipose tissue, and linking lymphatic function with metabolic diseases, obesity, and adipose tissue, also started to accumulate in the last years. Here we review our current knowledge of the mechanisms by which defective lymphatics contribute to obesity and fat accumulation in mouse models, as well as our understanding of the lymphatic-adipose tissue relationship. Obesity and cardiovascular diseases are leading causes of death and disability. In this Review, Oliver and Escobedo expose the relationships between lymphatics, metabolism, and obesity and discuss how this knowledge will provide us with better tools to diagnose and treat some of these pathological conditions. © 2017 Elsevier Inc.
dc.language.isoen
dc.publisherCell Press
dc.subjectadipose tissue
dc.subjectchyle
dc.subjectendothelial cell
dc.subjectinflammation
dc.subjectlymph
dc.subjectlymphatics
dc.subjectobesity
dc.subjectProx1
dc.subjectadipose tissue
dc.subjectangiogenesis
dc.subjectblood vessel
dc.subjectendothelium cell
dc.subjectfat intake
dc.subjecthuman
dc.subjectinflammation
dc.subjectintestine absorption
dc.subjectintestine lymph
dc.subjectlipid absorption
dc.subjectlipid metabolism
dc.subjectlipid storage
dc.subjectlymph vessel
dc.subjectmetabolic disorder
dc.subjectmouse model
dc.subjectnonhuman
dc.subjectobesity
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectReview
dc.subjectadipose tissue
dc.subjectanimal
dc.subjectlipid metabolism
dc.subjectlymph vessel
dc.subjectmetabolism
dc.subjectobesity
dc.subjectpathology
dc.subjectsignal transduction
dc.subjectAdipose Tissue
dc.subjectAdiposity
dc.subjectAnimals
dc.subjectHumans
dc.subjectInflammation
dc.subjectLipid Metabolism
dc.subjectLymphatic Vessels
dc.subjectObesity
dc.subjectSignal Transduction
dc.titleThe Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity
dc.typeReview


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