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Effects of curcumin on neurological diseases: focus on astrocytes

dc.contributor.authorEghbaliferiz S.
dc.contributor.authorFarhadi F.
dc.contributor.authorBarreto G.E.
dc.contributor.authorMajeed M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:17:16Z
dc.date.available2020-09-02T22:17:16Z
dc.date.issued2020
dc.identifier10.1007/s43440-020-00112-3
dc.identifier.citation72, 4, 769-782
dc.identifier.issn17341140
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4375
dc.descriptionAstrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative disease. Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. These effects are due to curcumin’s antioxidant, free-radical scavenging, and anti-inflammatory activity. In light of this, our current review aims to discuss the role of astrocytes as essential players in neurodegenerative diseases and suggest that curcumin is capable of direct inhibition of astrocyte activity with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, spinal cord injury, Multiple sclerosis, and Parkinson’s disease. © 2020, Maj Institute of Pharmacology Polish Academy of Sciences.
dc.language.isoen
dc.publisherSpringer
dc.subjectBrain
dc.subjectCurcuminoids
dc.subjectNeurodegenerative disease
dc.subjectcurcumin
dc.subjectAlzheimer disease
dc.subjectantiinflammatory activity
dc.subjectantioxidant activity
dc.subjectastrocyte
dc.subjectbrain edema
dc.subjectbrain ischemia
dc.subjectcell activation
dc.subjectdegenerative disease
dc.subjectdepression
dc.subjectdrug bioavailability
dc.subjectdrug mechanism
dc.subjectepilepsy
dc.subjectglioma
dc.subjecthuman
dc.subjectmicroglia
dc.subjectmultiple sclerosis
dc.subjectnervous system inflammation
dc.subjectneurologic disease
dc.subjectneuropathic pain
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectParkinson disease
dc.subjectPersian Gulf syndrome
dc.subjectReview
dc.subjectspinal cord injury
dc.titleEffects of curcumin on neurological diseases: focus on astrocytes
dc.typeReview


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