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Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications

dc.contributor.authorDíaz-Peña R.
dc.contributor.authorde los Santos M.J.
dc.contributor.authorLucia A.
dc.contributor.authorCastro-Santos P.
dc.date.accessioned2020-09-02T22:16:52Z
dc.date.available2020-09-02T22:16:52Z
dc.date.issued2019
dc.identifier10.1007/s10815-019-01426-9
dc.identifier.citation36, 5, 827-835
dc.identifier.issn10580468
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4364
dc.descriptionPregnancy is a unique immunological situation in which a fetus-bearing paternal histocompatibility antigens can survive in a maternal environment without apparent rejection. To face this challenge, cells of the uterine immune system show characteristic changes in absolute number and composition during pregnancy. Particularly relevant to this process are uterine natural killer (uNK) cells and their cell surface receptors, killer immunoglobulin-like receptors (KIRs). The main purpose of this review is to outline the current body of knowledge on the involvement of KIRs in the complications of pregnancy. Implantation depends on the invasion of embryonic trophoblast cells into maternal uterine tissue and remodeling of the uterine spiral arterioles, which is essential for placental perfusion and successful pregnancy. The proper interaction between maternal KIRs and their ligands human leukocyte antigen (HLA) class I molecules, expressed by the extravillous trophoblast cells, is crucial in this process. KIRs are a complex family that includes both activator and inhibitory receptors. The activation profile is genetically determined in each individual and leads to diverse levels of functionality for NK and T cells on engagement with specific HLA class I molecules. An association between different KIR alleles and HLA molecules has been reported in pregnancy complications, supporting the idea of a relevant role of these receptors in successful pregnancy. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherSpringer New York LLC
dc.subjectExtravillous trophoblast
dc.subjectHLA
dc.subjectKIR
dc.subjectRecurrent miscarriage
dc.subjectUterine natural killer
dc.subjectHLA antigen class 1
dc.subjectHLA C antigen
dc.subjectHLA G antigen
dc.subjectkiller cell immunoglobulin like receptor
dc.subjectHLA antigen
dc.subjectkiller cell immunoglobulin like receptor
dc.subjectallele
dc.subjectarteriole
dc.subjectfemale
dc.subjecthuman
dc.subjectlymphocyte subpopulation
dc.subjectnatural killer cell
dc.subjectplacenta perfusion
dc.subjectpregnancy complication
dc.subjectpriority journal
dc.subjectReview
dc.subjectspontaneous abortion
dc.subjecttrophoblast
dc.subjectuterus tissue
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectnidation
dc.subjectpathology
dc.subjectplacenta development
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.subjectEmbryo Implantation
dc.subjectFemale
dc.subjectHLA Antigens
dc.subjectHumans
dc.subjectKiller Cells, Natural
dc.subjectPlacentation
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectReceptors, KIR
dc.titleUnderstanding the role of killer cell immunoglobulin-like receptors in pregnancy complications
dc.typeReview


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