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Activating killer immunoglobulin-like receptors genes are associated with increased susceptibility to ankylosing spondylitis

dc.contributor.authorDíaz-Peña R.
dc.contributor.authorVidal-Castiñeira J.R.
dc.contributor.authorMulero J.
dc.contributor.authorSánchez A.
dc.contributor.authorQueiro R.
dc.contributor.authorLópez-Larrea C.
dc.date.accessioned2020-09-02T22:16:52Z
dc.date.available2020-09-02T22:16:52Z
dc.date.issued2015
dc.identifier10.1111/cei.12568
dc.identifier.citation180, 2, 201-206
dc.identifier.issn00099104
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4363
dc.descriptionThe aim of this study was to analyse the association of specific killer cell immunoglobulin-like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes was studied for their association with AS. A total of 176 patients with AS and 435 healthy control subjects were selected for this study based on clinical criteria. The commercial KIR-sequence-specific oligonucleotides (SSO) typing kit was used to investigate KIR typing. Frequencies of KIR2DS1 and KIR3DS1 genes were increased significantly in patients compared with healthy controls [52·8 versus 38·2%, P<inf>Bonf</inf> < 0·01, odds ratio (OR)=1·81 (1·28-2·59); 51·7 versus 37·5%, P<inf>Bonf</inf> < 0·01, OR=1·79 (1·25-2·54)]. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P<0·05). KIR2DS1 and KIR3DS1, in addition to human leucocyte antigen (HLA)-B27, may play an important role in the pathogenesis of AS. However, we show that the contribution of the KIR genes to AS susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to AS. © 2014 British Society for Immunology.
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectAnkylosing spondylitis
dc.subjectHLA-B27
dc.subjectKIR
dc.subjectSusceptibility
dc.subjectkiller cell immunoglobulin like receptor
dc.subjectkiller cell immunoglobulin like receptor 2DL1
dc.subjectkiller cell immunoglobulin like receptor 2DL2
dc.subjectkiller cell immunoglobulin like receptor 2DL3
dc.subjectkiller cell immunoglobulin like receptor 2DL4
dc.subjectkiller cell immunoglobulin like receptor 2DL5
dc.subjectkiller cell immunoglobulin like receptor 2DS1
dc.subjectkiller cell immunoglobulin like receptor 2DS2
dc.subjectkiller cell immunoglobulin like receptor 2DS3
dc.subjectkiller cell immunoglobulin like receptor 2DS4
dc.subjectkiller cell immunoglobulin like receptor 2DS5
dc.subjectkiller cell immunoglobulin like receptor 3DL1
dc.subjectkiller cell immunoglobulin like receptor 3DS1
dc.subjectunclassified drug
dc.subjectHLA B27 antigen
dc.subjectkiller cell immunoglobulin like receptor
dc.subjectkiller cell immunoglobulin like receptor 3DS1
dc.subjectKIR2DS1 protein, human
dc.subjectadult
dc.subjectankylosing spondylitis
dc.subjectArticle
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdisease predisposition
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectgenetic predisposition
dc.subjectgenotype
dc.subjecthaplotype
dc.subjecthuman
dc.subjectimmunopathogenesis
dc.subjectmajor clinical study
dc.subjectpriority journal
dc.subjectSpain
dc.subjectankylosing spondylitis
dc.subjectclinical trial
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectgenotype
dc.subjectgenotyping technique
dc.subjectimmunology
dc.subjectmale
dc.subjectmulticenter study
dc.subjectpathology
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectGenotyping Techniques
dc.subjectHLA-B27 Antigen
dc.subjectHumans
dc.subjectMale
dc.subjectReceptors, KIR
dc.subjectReceptors, KIR3DS1
dc.subjectSpondylitis, Ankylosing
dc.titleActivating killer immunoglobulin-like receptors genes are associated with increased susceptibility to ankylosing spondylitis
dc.typeArticle


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