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Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn's disease

dc.contributor.authorDíaz-Peña R.
dc.contributor.authorVidal-Castiñeira J.R.
dc.contributor.authorMoro-García M.A.
dc.contributor.authorAlonso-Arias R.
dc.contributor.authorCastro-Santos P.
dc.date.accessioned2020-09-02T22:16:52Z
dc.date.available2020-09-02T22:16:52Z
dc.date.issued2016
dc.identifier10.1016/j.humimm.2015.10.020
dc.identifier.citation77, 1, 104-109
dc.identifier.issn01988859
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4362
dc.descriptionWe aimed to analyze the possible association of KIR/HLA-C genotypes with the susceptibility to Crohn's disease (CD) in a Spanish population. A total of 125 patients with CD and 339 healthy controls were selected for this study. KIR and HLA-C typing were developed by sequence-specific oligonucleotide probing. We found that the centromeric A/A genotype and HLA-C1 combination was significantly increased in CD patients (P < 10-3). The KIR2DL3/2DL3 genotype was significantly increased in CD patients (P < 0.0005). Moreover, we also observed a highly significant increase of KIR2DL3-HLA-C1 homozygosis in CD patients (P < 0.0005). Our results confirm the relevance of the KIR2DL2/KIR2DL3 genes and their interaction with HLA-C to CD. We show that the contribution of the KIR genes to CD susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to CD. © 2015 American Society for Histocompatibility and Immunogenetics.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectCrohn's disease
dc.subjectHLA
dc.subjectKIR
dc.subjectNatural killer
dc.subjectHLA C antigen
dc.subjectkiller cell immunoglobulin like receptor 2DL3
dc.subjectHLA C antigen
dc.subjectkiller cell immunoglobulin like receptor 2DL2
dc.subjectkiller cell immunoglobulin like receptor 2DL3
dc.subjectKIR2DL2 protein, human
dc.subjectKIR2DL3 protein, human
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectCrohn disease
dc.subjectgene interaction
dc.subjectgenetic association
dc.subjectgenetic susceptibility
dc.subjectgenotype
dc.subjecthomozygosity
dc.subjecthuman
dc.subjectimmunogenetics
dc.subjectimmunopathogenesis
dc.subjectmajor clinical study
dc.subjectpriority journal
dc.subjectSpaniard
dc.subjectCrohn disease
dc.subjectgene frequency
dc.subjectgene linkage disequilibrium
dc.subjectgenetic association study
dc.subjectgenetic polymorphism
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectimmunology
dc.subjectnatural killer cell
dc.subjectSpain
dc.subjectCrohn Disease
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHLA-C Antigens
dc.subjectHumans
dc.subjectKiller Cells, Natural
dc.subjectLinkage Disequilibrium
dc.subjectPolymorphism, Genetic
dc.subjectReceptors, KIR2DL2
dc.subjectReceptors, KIR2DL3
dc.subjectSpain
dc.titleSignificant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn's disease
dc.typeArticle


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