Mostrar el registro sencillo del ítem

Synthesis of five known brassinosteroid analogs from hyodeoxycholic acid and their activities as plant-growth regulators

dc.contributor.authorDuran M.I.
dc.contributor.authorGonzález C.
dc.contributor.authorAcosta A.
dc.contributor.authorOlea A.F.
dc.contributor.authorDíaz K.
dc.contributor.authorEspinoza L.
dc.date.accessioned2020-09-02T22:16:42Z
dc.date.available2020-09-02T22:16:42Z
dc.date.issued2017
dc.identifier10.3390/ijms18030516
dc.identifier.citation18, 3, -
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4299
dc.descriptionBrassinosteroids (BRs) are plant hormones that promote growth in different plant organs and tissues. The structural requirements that these compounds should possess to exhibit this biological activity have been studied. In this work, a series of known BR analogs 5-15, were synthesized starting from hyodeoxycholic acid 4, and maintaining the alkyl side chain as cholic acid or its methyl ester. The growth-promoting effects of brassinolide (1) and synthesized analogs were evaluated by using the rice lamina inclination assay at concentrations ranging from 1 × 10-8-1 × 10-6 M. Our results indicate that in this concentration range the induced bending angle of rice seedlings increases with increasing concentration of BRs. Analysis of the activities, determined at the lowest tested concentration, in terms of BR structures shows that the 2α,3α-dihydroxy-7-oxa-6-ketone moiety existing in brassinolide is required for the plant growing activity of these compounds, as it has been proposed by some structure-activity relationship studies. The effect of compound 8 on cell elongation was assessed by microscopy analysis, and the results indicate that the growth-promoting effect of analog 8 is mainly due to cell elongation of the adaxial sides, instead of an increase on cell number. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectBrassinosteroid analogs
dc.subjectLamina inclination test
dc.subjectPlant-growth regulators
dc.subjectSynthesis
dc.subjectacid 3 alpha hydroxy 6 oxa 7 oxo 5 alpha cholan 24 oic
dc.subjectacid 3 alpha hydroxy 6 oxo 7 oxa 5 alpha cholan 24 oic
dc.subjectbrassinolide
dc.subjectbrassinosteroid
dc.subjecthyodeoxycholic acid
dc.subjectmethyl 2 alpha 3 alpha dihydroxy 6 oxo 5 alpha cholan 24 oate
dc.subjectmethyl 2 en 6 oxo 5 alpha cholan 24 oate
dc.subjectmethyl 3 alpha acetoxy 6 oxa 7 oxo 5 alpha cholan 24 oate
dc.subjectmethyl 3 alpha acetoxy 6 oxo 5 alpha cholan 24 oate
dc.subjectmethyl 3 alpha acetoxy 6 oxo 7 oxa 5 alpha cholan 24 oate
dc.subjectphytohormone
dc.subjectunclassified drug
dc.subjectbrassinosteroid
dc.subjectdeoxycholic acid
dc.subjecthyodeoxycholic acid
dc.subjectphytohormone
dc.subjectArticle
dc.subjectbioassay
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcolumn chromatography
dc.subjectcontrolled study
dc.subjectdrug synthesis
dc.subjectheteronuclear multiple bond correlation
dc.subjectheteronuclear single quantum coherence
dc.subjecthuman
dc.subjectinfrared spectroscopy
dc.subjectmesophyll cell
dc.subjectplant growth
dc.subjectproton nuclear magnetic resonance
dc.subjectrice lamina inclination bioassay
dc.subjectsaponification
dc.subjectstructure activity relation
dc.subjectthin layer chromatography
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectgrowth, development and aging
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectOryza
dc.subjectseedling
dc.subjectsynthesis
dc.subjectBrassinosteroids
dc.subjectDeoxycholic Acid
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMolecular Structure
dc.subjectOryza
dc.subjectPlant Growth Regulators
dc.subjectSeedlings
dc.titleSynthesis of five known brassinosteroid analogs from hyodeoxycholic acid and their activities as plant-growth regulators
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85014827888.pdf
Tamaño:
3.590Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem