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Novel alkylimidazolium ionic liquids as an antibacterial alternative to pathogens of the skin and soft tissue infections

dc.contributor.authorDoria O.F.
dc.contributor.authorCastro R.
dc.contributor.authorGutierrez M.
dc.contributor.authorValenzuela D.G.
dc.contributor.authorSantos L.
dc.contributor.authorRamirez D.
dc.contributor.authorGuzman L.
dc.date.accessioned2020-09-02T22:16:41Z
dc.date.available2020-09-02T22:16:41Z
dc.date.issued2018
dc.identifier10.3390/molecules23092354
dc.identifier.citation23, 9, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4288
dc.descriptionKeeping in mind the concept of green chemistry, this research aims to synthesize and characterize new ionic liquids (ILs) derived from N-cinnamyl imidazole with different sizes of alkyl chains (1, 6, 8, and 10 carbon atoms), and evaluate their antibacterial activity against Skin and soft tissue infections (SSTIs) causative bacteria. The antibacterial screening was carried out by agar well diffusion and the Minimum Inhibitory Concentration (MIC) and Half Maximum Inhibitory Concentration (IC50) of the different ILs were determined by microdilution in broth, also Molecular dynamics simulations were performed to study the interaction mechanism between ILs and membranes. The MIC value in Gram-positive bacteria showed that as the hydrocarbon chain increases, the MIC value decreases with a dose-dependent effect. Furthermore, Gram-negative bacteria showed high MIC values, which were also evidenced in the antibacterial screening. The molecular dynamics showed an incorporation of the ILs with the longer chain (10 C), corresponding to a passive diffusion towards the membrane surface, for its part, the ILs with the shorter chain due to its lack of hydrophobicity was not incorporated into the bilayer. Finally, the new ILs synthesized could be an alternative for the treatment of Gram-positive bacteria causative of SSTIs. © 2018 MDPI AG. All rights reserved.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntibacterial
dc.subjectIonic liquids
dc.subjectSkin
dc.subjectSoft tissue infections
dc.subjectantiinfective agent
dc.subjectimidazole derivative
dc.subjectionic liquid
dc.subjectanimal
dc.subjectchemistry
dc.subjectdose response
dc.subjectdrug effect
dc.subjectGram negative bacterium
dc.subjectGram positive bacterium
dc.subjectgreen chemistry
dc.subjecthuman
dc.subjectmicrobial sensitivity test
dc.subjectmolecular dynamics
dc.subjectsoft tissue infection
dc.subjectstaphylococcal skin infection
dc.subjectsynthesis
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectDose-Response Relationship, Drug
dc.subjectGram-Negative Bacteria
dc.subjectGram-Positive Bacteria
dc.subjectGreen Chemistry Technology
dc.subjectHumans
dc.subjectImidazoles
dc.subjectIonic Liquids
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Dynamics Simulation
dc.subjectSoft Tissue Infections
dc.subjectStaphylococcal Skin Infections
dc.titleNovel alkylimidazolium ionic liquids as an antibacterial alternative to pathogens of the skin and soft tissue infections
dc.typeArticle


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