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Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: Targeting neurological and mental disorders

dc.contributor.authorDhiman P.
dc.contributor.authorMalik N.
dc.contributor.authorSobarzo-Sánchez E.
dc.contributor.authorUriarte E.
dc.contributor.authorKhatkar A.
dc.date.accessioned2020-09-02T22:16:17Z
dc.date.available2020-09-02T22:16:17Z
dc.date.issued2019
dc.identifier10.3390/molecules24030418
dc.identifier.citation24, 3, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4265
dc.descriptionMonoamine oxidase inhibitions are considered as important targets for the treatment of depression, anxiety, and neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. This has encouraged many medicinal chemistry research groups for the development of most promising selective monoamine oxidase (MAO) inhibitors. A large number of plant isolates also reported for significant MAO inhibition potential in recent years. Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors. Flavonoid scaffold showed notable antidepressant and neuroprotective properties as revealed by various and established preclinical trials. The current review made an attempt to summarizing and critically evaluating the new findings on the quercetin and related flavonoid derivatives functions as potent MAO isoform inhibitors. © 2019 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectFlavonoids
dc.subjectIn-silico design
dc.subjectMental disorders
dc.subjectMonoamine oxidase
dc.subjectMonoamine oxidase inhibitors
dc.subjectNeurodegenerative disorder
dc.subjectQuercetin
dc.subjectflavonoid
dc.subjectmonoamine oxidase inhibitor
dc.subjectquercetin
dc.subjectanimal
dc.subjectchemical phenomena
dc.subjectchemistry
dc.subjecthuman
dc.subjectmental disease
dc.subjectmetabolism
dc.subjectmolecular model
dc.subjectneurologic disease
dc.subjectstructure activity relation
dc.subjectAnimals
dc.subjectChemical Phenomena
dc.subjectFlavonoids
dc.subjectHumans
dc.subjectMental Disorders
dc.subjectModels, Molecular
dc.subjectMonoamine Oxidase Inhibitors
dc.subjectNervous System Diseases
dc.subjectQuercetin
dc.subjectStructure-Activity Relationship
dc.titleQuercetin and related chromenone derivatives as monoamine oxidase inhibitors: Targeting neurological and mental disorders
dc.typeReview


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