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Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats

dc.contributor.authorDel Rio R.
dc.contributor.authorAndrade D.C.
dc.contributor.authorLucero C.
dc.contributor.authorArias P.
dc.contributor.authorIturriaga R.
dc.date.accessioned2020-09-02T22:16:13Z
dc.date.available2020-09-02T22:16:13Z
dc.date.issued2016
dc.identifier10.1161/HYPERTENSIONAHA.116.07255
dc.identifier.citation68, 2, 436-445
dc.identifier.issn0194911X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4242
dc.descriptionChronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, enhances carotid body (CB) chemosensory responses to hypoxia and produces autonomic dysfunction, cardiac arrhythmias, and hypertension. We tested whether autonomic alterations, arrhythmogenesis, and the progression of hypertension induced by CIH depend on the enhanced CB chemosensory drive, by ablation of the CB chemoreceptors. Male Sprague-Dawley rats were exposed to control (Sham) conditions for 7 days and then to CIH (5% O2, 12/h 8 h/d) for a total of 28 days. At 21 days of CIH exposure, rats underwent bilateral CB ablation and then exposed to CIH for 7 additional days. Arterial blood pressure and ventilatory chemoreflex response to hypoxia were measured in conscious rats. In addition, cardiac autonomic imbalance, cardiac baroreflex gain, and arrhythmia score were assessed during the length of the experiments. In separate experimental series, we measured extracellular matrix remodeling content in cardiac atrial tissue and systemic oxidative stress. CIH induced hypertension, enhanced ventilatory response to hypoxia, induced autonomic imbalance toward sympathetic preponderance, reduced baroreflex gain, and increased arrhythmias and atrial fibrosis. CB ablation normalized blood pressure, reduced ventilatory response to hypoxia, and restored cardiac autonomic and baroreflex function. In addition, CB ablation reduced the number of arrhythmias, but not extracellular matrix remodeling or systemic oxidative stress, suggesting that reductions in arrhythmia incidence during CIH were related to normalization of cardiac autonomic balance. Present results show that autonomic alterations induced by CIH are critically dependent on the CB and support a main role for the CB in the CIH-induced hypertension. © 2016 American Heart Association, Inc.
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.subjectblood pressure
dc.subjectcardiac arrhythmias
dc.subjectextracellular matrix
dc.subjecthypertension
dc.subjectobstructive sleep apnea
dc.subjectgelatinase A
dc.subjecttissue inhibitor of metalloproteinase 2
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarrhythmogenesis
dc.subjectarterial pressure
dc.subjectArticle
dc.subjectautonomic dysfunction
dc.subjectbreathing rate
dc.subjectcardiorespiratory fitness
dc.subjectcarotid body ablation
dc.subjectcarotid body chemoreceptor
dc.subjectchemoreceptor reflex
dc.subjectchronic intermittent hypoxia
dc.subjectconsciousness
dc.subjectcontrolled study
dc.subjectcryoablation
dc.subjectdiastolic blood pressure
dc.subjectdisease course
dc.subjectextracellular matrix
dc.subjectheart arrhythmia
dc.subjectheart atrium
dc.subjectheart function
dc.subjectheart muscle fibrosis
dc.subjecthypertension
dc.subjectlung minute volume
dc.subjectlung ventilation
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpressoreceptor reflex
dc.subjectpriority journal
dc.subjectrat
dc.subjectsystolic blood pressure
dc.subjecttidal volume
dc.subjectablation therapy
dc.subjectanimal
dc.subjectArrhythmias, Cardiac
dc.subjectblood pressure
dc.subjectcarotid body
dc.subjectchemoreceptor cell
dc.subjectcomplication
dc.subjectdisease model
dc.subjecthypertension
dc.subjecthypoxia
dc.subjectpathophysiology
dc.subjectphysiologic monitoring
dc.subjectphysiology
dc.subjectprocedures
dc.subjectSprague Dawley rat
dc.subjecttreatment outcome
dc.subjectAblation Techniques
dc.subjectAnimals
dc.subjectArrhythmias, Cardiac
dc.subjectBlood Pressure
dc.subjectCarotid Body
dc.subjectChemoreceptor Cells
dc.subjectDisease Models, Animal
dc.subjectHypertension
dc.subjectHypoxia
dc.subjectMonitoring, Physiologic
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectTreatment Outcome
dc.titleCarotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats
dc.typeArticle


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