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The role of protein SUMOylation in rheumatoid arthritis

dc.contributor.authorDehnavi S.
dc.contributor.authorSadeghi M.
dc.contributor.authorJohnston T.P.
dc.contributor.authorBarreto G.
dc.contributor.authorShohan M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:16:12Z
dc.date.available2020-09-02T22:16:12Z
dc.date.issued2019
dc.identifier10.1016/j.jaut.2019.05.006
dc.identifier.citation102, , 1-7
dc.identifier.issn08968411
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4234
dc.descriptionSmall ubiquitin-like modifier (SUMO) proteins, as a subgroup of post-translational modifiers, act to change the function of proteins. Through their interactions with different targets, immune pathways, and the responses they elicit, can be affected by these SUMO conjugations. Thus, both a change to protein function and involvement in immune pathways has the potential to promote an efficient immune response to either a pathogenic challenge, or the development of an imbalance that could lead to an autoimmune-based disease. Also, a variety of changes such as mutations and polymorphisms can interfere with common functions of these modifications and move an effective immune response in the direction of an autoimmune disease. The present review discusses the general characteristics of SUMO proteins and focuses on their involvement in rheumatoid arthritis as an autoimmune disease. © 2019 Elsevier Ltd
dc.language.isoen
dc.publisherAcademic Press
dc.subjectPost-translational modifications
dc.subjectProteins
dc.subjectRheumatoid arthritis
dc.subjectSmall ubiquitin-like modifier
dc.subjectcollagenase 3
dc.subjectinterstitial collagenase
dc.subjectstromelysin
dc.subjectSUMO protein
dc.subjectSUMO protein
dc.subjectapoptosis
dc.subjectautoimmunity
dc.subjectcartilage
dc.subjectgenetic susceptibility
dc.subjecthuman
dc.subjectimmunopathogenesis
dc.subjectinflammation
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectReview
dc.subjectrheumatoid arthritis
dc.subjectsingle nucleotide polymorphism
dc.subjectsumoylation
dc.subjectgenetic polymorphism
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectpathology
dc.subjectphysiology
dc.subjectproteomics
dc.subjectrheumatoid arthritis
dc.subjectsumoylation
dc.subjectArthritis, Rheumatoid
dc.subjectAutoimmunity
dc.subjectHumans
dc.subjectInflammation
dc.subjectPolymorphism, Genetic
dc.subjectProteomics
dc.subjectSmall Ubiquitin-Related Modifier Proteins
dc.subjectSumoylation
dc.titleThe role of protein SUMOylation in rheumatoid arthritis
dc.typeReview


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