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Circulating inflammatory miRNA signature in response to different doses of aerobic exercise

dc.contributor.authorDe Gonzalo-Calvo D.
dc.contributor.authorDávalos A.
dc.contributor.authorMontero A.
dc.contributor.authorGarcía-González Á.
dc.contributor.authorTyshkovska I.
dc.contributor.authorGonzález-Medina A.
dc.contributor.authorSoares S.M.A.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorCasas-Agustench P.
dc.contributor.authorRabadán M.
dc.contributor.authorDíaz-Martínez Á.E.
dc.contributor.authorÚbeda N.
dc.contributor.authorIglesias-Gutiérrez E.
dc.date.accessioned2020-09-02T22:16:09Z
dc.date.available2020-09-02T22:16:09Z
dc.date.issued2015
dc.identifier10.1152/japplphysiol.00077.2015
dc.identifier.citation119, 2, 124-134
dc.identifier.issn87507587
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4220
dc.descriptionWhile moderate acute exercise has been associated with strong anti-inflammatory mechanisms, strenuous exercise has been linked to deleterious inflammatory perturbations. It is therefore fundamental to elucidate the mechanisms that regulate the exercise-induced inflammatory cascade. Information on novel regulators such as circulating inflammatory microRNAs (c-inflammamiRs) is incomplete. In this study, we evaluated the response of a panel of c-inflammamiRs to different doses of acute aerobic exercise. We first studied the exercise-induced inflammatory cascade in serum samples of nine active middle-aged males immediately before and after (0 h, 24 h, 72 h) 10-km, half-marathon, and marathon races. Next, we analyzed the circulating profile of 106 specific c-inflammamiRs immediately before) and after (0 h, 24 h) 10-km (low inflammatory response) and marathon (high inflammatory response) races. Analysis of classical inflammatory parameters revealed a dose-dependent effect of aerobic exercise on systemic inflammation, with higher levels detected after marathon. We observed an increase in miR-150-5p immediately after the 10-km race. Levels of 12 c-inflammamiRs were increased immediately after the marathon (let-7d-3p, let-7f-2-3p, miR-125b-5p, miR-132-3p, miR-143-3p, miR- 148a-3p, miR-223-3p, miR-223-5p, miR-29a-3p, miR-34a-5p, miR- 424-3p, and miR-424-5p). c-inflammamiRs returned to basal levels after 24 h. Correlation and in silico analyses supported a close association between the observed c-inflammamiR pattern and regulation of the inflammatory process. In conclusion, we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose. Copyright © 2015 the American Physiological Society.
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.subjectCirculating microRNAs
dc.subjectExercise
dc.subjectInflammation
dc.subjectbiological marker
dc.subjectmicroRNA
dc.subjectadult
dc.subjectblood
dc.subjectexercise
dc.subjecthuman
dc.subjectinflammation
dc.subjectmale
dc.subjectphysiology
dc.subjectrunning
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectExercise
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectMicroRNAs
dc.subjectRunning
dc.titleCirculating inflammatory miRNA signature in response to different doses of aerobic exercise
dc.typeArticle


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