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Serum uric acid levels and risk of developing preeclampsia [Niveles de ácido úrico sérico y riesgo de desarrollar preeclampsia]

dc.contributor.authorCorominas A.I.
dc.contributor.authorBalconi S.M.
dc.contributor.authorPalermo M.
dc.contributor.authorMaskin B.
dc.contributor.authorDamiano A.E.
dc.date.accessioned2020-09-02T22:15:30Z
dc.date.available2020-09-02T22:15:30Z
dc.date.issued2014
dc.identifier.citation74, 6, 462-471
dc.identifier.issn00257680
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4079
dc.descriptionIt is well known that preeclampsia is associated to high uric acid levels, but the clinical assessment of this relationship is still under consideration. Our research was to evaluate if periodic doses of uric acid during pregnancy might help to identify a high risk group prior to the onset of preeclampsia. We conducted a retrospective investigation in 79 primary gestates with normal blood pressure and 79 women with preeclampsia who were assisted at Hospital Nacional Posadas during 2010. Serum uric acid levels, creatininemia, uremia, and proteinuria data from the clinical records of the pregnant women were considered. Uric acid levels were similar in both groups during the first half of gestation. However, as of the 20th week, uric acid increased 1.5-times in preeclamptic women with no changes in creatinine and urea, confirming that these patients had no renal complications. Furthermore, we noted that higher levels of uric acid correlated with low birth weight. We also observed that pregnant women with a family history of hypertension were more likely to develop this condition. Moreover, we did not find a direct relationship with the fetal sex or the appearance of clinical symptoms. The analytical evidence suggests that changes in uric acid concentrations may be due to metabolic alterations at the initial stages of preeclampsia. Therefore, we propose that monitoring levels of uric acid during pregnancy might contribute to the early control of this condition. © 2014, Instituto de Investigaciones Medicas. All rights reserved.
dc.language.isoes
dc.publisherInstituto de Investigaciones Medicas
dc.subjectGestation
dc.subjectPreeclampsia
dc.subjectUric acid
dc.subjectcreatinine
dc.subjectprotein
dc.subjecturea
dc.subjecturic acid
dc.subjectcreatinine
dc.subjecturea
dc.subjecturic acid
dc.subjectabnormally high substrate concentration in blood
dc.subjectArticle
dc.subjectblood pressure
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectcreatininemia
dc.subjectevaluation study
dc.subjectfamily history
dc.subjectfemale
dc.subjectgestational age
dc.subjecthigh risk population
dc.subjecthuman
dc.subjecthypertension
dc.subjectlow birth weight
dc.subjectmajor clinical study
dc.subjectpreeclampsia
dc.subjectpregnancy
dc.subjectpregnant woman
dc.subjectprotein blood level
dc.subjectproteinuria
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjecturea blood level
dc.subjecturemia
dc.subjecturic acid blood level
dc.subjectadult
dc.subjectbirth weight
dc.subjectblood
dc.subjectcomplication
dc.subjectearly diagnosis
dc.subjectparity
dc.subjectPre-Eclampsia
dc.subjectprognosis
dc.subjectsecond trimester pregnancy
dc.subjectyoung adult
dc.subjectAdult
dc.subjectBirth Weight
dc.subjectCreatinine
dc.subjectEarly Diagnosis
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectInfant, Low Birth Weight
dc.subjectParity
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectPregnancy Trimester, Second
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectUrea
dc.subjectUric Acid
dc.subjectYoung Adult
dc.titleSerum uric acid levels and risk of developing preeclampsia [Niveles de ácido úrico sérico y riesgo de desarrollar preeclampsia]
dc.typeArticle


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