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Immunohistochemical localization of periostin in human gingiva

dc.contributor.authorCobo T.
dc.contributor.authorObaya A.
dc.contributor.authorCal S.
dc.contributor.authorSolares L.
dc.contributor.authorCabo R.
dc.contributor.authorVega J.A.
dc.contributor.authorCobo J.
dc.date.accessioned2020-09-02T22:14:55Z
dc.date.available2020-09-02T22:14:55Z
dc.date.issued2015
dc.identifier10.4081/ejh.2015.2548
dc.identifier.citation59, 3, 207-210
dc.identifier.issn1121760X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4039
dc.descriptionThe periostin is a matricellular protein expressed in collagen-rich tissues including some dental and periodontal tissues where it is regulated by mechanical forces, growth factors and cytokines. Interestingly the expression of this protein has been found modified in different gingival pathologies although the expression of periostin in normal human gingiva was never investigated. Here we used Western blot and double immunofluorescence coupled to laser-confocal microscopy to investigated the occurrence and distribution of periostin in different segments of the human gingival in healthy subjects. By Western blot a protein band with an estimated molecular mass of 94 kDa was observed. Periostin was localized at the epithelial-connective tissue junction, or among the fibers of the periodontal ligament, and never co-localized with cytokeratin or vimentin thus suggesting it is an extracellular protein. These results demonstrate the occurrence of periostin in adult human gingiva; its localization suggests a role in the bidirectional interactions between the connective tissue and the epithelial cells, and therefore in the physiopathological conditions in which these interactions are altered. © Copyright T. Cobo et al., 2015.
dc.language.isoen
dc.publisherLuigi Ponzio e figlio Editori
dc.subjectHuman gingiva
dc.subjectMatricellular proteins
dc.subjectPeriostin
dc.subjectcell adhesion molecule
dc.subjectkeratin
dc.subjectPOSTN protein, human
dc.subjectvimentin
dc.subjectadolescent
dc.subjectadult
dc.subjectcytology
dc.subjectfemale
dc.subjectgingiva
dc.subjecthuman
dc.subjectmale
dc.subjectmetabolism
dc.subjectperiodontal ligament
dc.subjectAdolescent
dc.subjectAdult
dc.subjectCell Adhesion Molecules
dc.subjectFemale
dc.subjectGingiva
dc.subjectHumans
dc.subjectKeratins
dc.subjectMale
dc.subjectPeriodontal Ligament
dc.subjectVimentin
dc.titleImmunohistochemical localization of periostin in human gingiva
dc.typeArticle


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