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Searching for proprioceptors in human facial muscles

dc.contributor.authorCobo J.L.
dc.contributor.authorAbbate F.
dc.contributor.authorde Vicente J.C.
dc.contributor.authorCobo J.
dc.contributor.authorVega J.A.
dc.date.accessioned2020-09-02T22:14:54Z
dc.date.available2020-09-02T22:14:54Z
dc.date.issued2017
dc.identifier10.1016/j.neulet.2017.01.016
dc.identifier.citation640, , 1-5
dc.identifier.issn03043940
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4035
dc.descriptionThe human craniofacial muscles innervated by the facial nerve typically lack muscle spindles. However these muscles have proprioception that participates in the coordination of facial movements. A functional substitution of facial proprioceptors by cutaneous mechanoreceptors has been proposed but at present this alternative has not been demonstrated. Here we have investigated whether other kinds of sensory structures are present in two human facial muscles (zygomatic major and buccal). Human checks were removed from Spanish cadavers, and processed for immunohistochemical detection of nerve fibers (neurofilament proteins and S100 protein) and two putative mechanoproteins (acid-sensing ion channel 2 and transient receptor potential vanilloid 4) associated with mechanosensing. Nerves of different calibers were found in the connective septa and within the muscle itself. In all the muscles analysed, capsular corpuscle-like structures resembling elongated or round Ruffini-like corpuscles were observed. Moreover the axon profiles within these structures displayed immunoreactivity for both putative mechanoproteins. The present results demonstrate the presence of sensory structures in facial muscles that can substitute for typical muscle spindles as the source of facial proprioception. © 2017 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectFacial muscles
dc.subjectMechanoproteins
dc.subjectProprioceptors
dc.subjectSensory corpuscle-like structures
dc.subjectvanilloid receptor 4
dc.subjectacid sensing ion channel
dc.subjectASIC2 protein, human
dc.subjectTRPV4 protein, human
dc.subjectvanilloid receptor
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcadaver
dc.subjectface muscle
dc.subjectfacial nerve
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunoreactivity
dc.subjectmale
dc.subjectmechanoreceptor
dc.subjectmuscle spindle
dc.subjectpriority journal
dc.subjectproprioception
dc.subjectquantitative analysis
dc.subjectSchwann cell
dc.subjectsuperficial musculoaponeurotic system
dc.subjecttrigeminal nerve
dc.subjectanatomy and histology
dc.subjectcheek
dc.subjectface muscle
dc.subjectinnervation
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectAcid Sensing Ion Channels
dc.subjectAged
dc.subjectCheek
dc.subjectFacial Muscles
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMechanoreceptors
dc.subjectMiddle Aged
dc.subjectProprioception
dc.subjectTRPV Cation Channels
dc.titleSearching for proprioceptors in human facial muscles
dc.typeArticle


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