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Relationship between glycaemic levels and arterial stiffness in non-diabetic adults [Relación entre los valores de glucemia y la rigidez arterial en adultos no diabéticos]

dc.contributor.authorCavero-Redondo I.
dc.contributor.authorMartínez-Vizcaíno V.
dc.contributor.authorÁlvarez-Bueno C.
dc.contributor.authorRecio-Rodríguez J.I.
dc.contributor.authorGómez-Marcos M.Á.
dc.contributor.authorGarcía-Ortiz L.
dc.date.accessioned2020-09-02T22:14:53Z
dc.date.available2020-09-02T22:14:53Z
dc.date.issued2018
dc.identifier10.1016/j.medcli.2017.06.072
dc.identifier.citation150, 2, 56-60
dc.identifier.issn00257753
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4026
dc.descriptionObjective To examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c). Patient population and methods A cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined. Mean differences in arterial stiffness-related parameters by HbA1c and FPG tertiles were tested using analysis of covariance. Results All means of arterial stiffness-related parameters increased by HbA1c tertiles, although mean differences were only statistically significant in pulse wave velocity (p ≤.001), even after controlling for potential confounders (HbA1c <5.30% = 6.88 m/s; HbA1c 5.30%-5.59% = 7.06 m/s; and HbA1c ≥5.60% = 8.16 m/s, p =.004). Conversely, mean differences in pulse wave velocity by FPG tertiles did not reach statistically significant differences after controlling for potential confounders (FPG 4.44 mmol/l = 7.18 m/s; FPG 4.44 mmol/l-4.87 mmol/l = 7.26 m/s; and FPG ≥4.88 mmol/l = 7.93 m/s, p =.066). Conclusions Glucose levels in a non-diabetic population were associated with arterial stiffness but better when levels were determined using HbA1c. © 2017 Elsevier España, S.L.U.
dc.language.isoen
dc.language.isoes
dc.publisherEdiciones Doyma, S.L.
dc.subjectArterial stiffness
dc.subjectFasting plasma glucose
dc.subjectGlycated haemoglobin
dc.subjectHbA1c
dc.subjectPulse wave velocity
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjectbiological marker
dc.subjectglycosylated hemoglobin
dc.subjecthemoglobin A1c protein, human
dc.subjectarterial stiffness
dc.subjectArticle
dc.subjectaugmentation index
dc.subjectcorrelational study
dc.subjectcross-sectional study
dc.subjectdiet restriction
dc.subjectglucose blood level
dc.subjecthemoglobin blood level
dc.subjecthuman
dc.subjectpulse pressure
dc.subjectpulse wave
dc.subjectadult
dc.subjectarterial stiffness
dc.subjectblood
dc.subjectblood pressure
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectglucose tolerance test
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectBlood Glucose
dc.subjectBlood Pressure
dc.subjectCross-Sectional Studies
dc.subjectFasting
dc.subjectFemale
dc.subjectGlucose Tolerance Test
dc.subjectGlycated Hemoglobin A
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPulse Wave Analysis
dc.subjectVascular Stiffness
dc.titleRelationship between glycaemic levels and arterial stiffness in non-diabetic adults [Relación entre los valores de glucemia y la rigidez arterial en adultos no diabéticos]
dc.typeArticle


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