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A synopsis on the linkage between age-related dementias and vascular disorders

dc.contributor.authorChibber S.
dc.contributor.authorAlexiou A.
dc.contributor.authorAlama M.N.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAliev G.
dc.contributor.authorAshraf G.M.
dc.date.accessioned2020-09-02T22:14:52Z
dc.date.available2020-09-02T22:14:52Z
dc.date.issued2016
dc.identifier10.2174/1871527315666160202121809
dc.identifier.citation15, 2, 250-258
dc.identifier.issn18715273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4019
dc.descriptionThe concept of age-related dementias and vascular disorders has now been recognized for over a century. In the present review, we have emphasized on the causes, consequences and the true bases for the treatment and prevention of these disorders. Systematic efforts have been put together to identify the aetiology in each case. Increased efforts have been targeted towards the concept and genetic factors responsible for vascular cognitive impairment and post-stroke dementia in relation with Alzheimer’s disease, which is a consequence of age-related dementia, especially as they hold promise for early prevention and treatment. It has now been well accepted that vascular dementia is not a single disease but a group of conditions with different pathological correlations and pathophysiological mechanisms. The present review represents an amalgamation of several pathophysiological mechanisms producing a very heterogeneous clinical presentation for developing such consequences. We suggest current diagnostic categories and describe clinical parameters according to recently reported studies that document the demographic data in a standardized manner for age-related dementia disorders. © 2016 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectMitochondrial lesion
dc.subjectPost stroke dementia
dc.subjectReactive oxygen species
dc.subjectVascular dementia
dc.subjectdonepezil
dc.subjectgalantamine
dc.subjectGinkgo biloba extract
dc.subjecthuperzine A
dc.subjectnitric oxide
dc.subjectreactive oxygen metabolite
dc.subjectrivastigmine
dc.subjectapoptosis
dc.subjectbrain ischemia
dc.subjectcognitive defect
dc.subjectdementia
dc.subjectenvironmental factor
dc.subjectgene mutation
dc.subjecthuman
dc.subjectmeta analysis (topic)
dc.subjectmitochondrial permeability
dc.subjectmultiinfarct dementia
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectoxidative phosphorylation
dc.subjectpathogenesis
dc.subjectphenotype
dc.subjectprotein expression
dc.subjectReview
dc.subjectsignal transduction
dc.subjectvascular disease
dc.subjectaging
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectcerebrovascular accident
dc.subjectCognitive Dysfunction
dc.subjectdementia
dc.subjectDementia, Vascular
dc.subjectmetabolism
dc.subjectpathology
dc.subjectVascular Diseases
dc.subjectAging
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectCognitive Dysfunction
dc.subjectDementia
dc.subjectDementia, Vascular
dc.subjectHumans
dc.subjectStroke
dc.subjectVascular Diseases
dc.titleA synopsis on the linkage between age-related dementias and vascular disorders
dc.typeReview


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