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In vitro antifungal activity of new and known geranylated phenols against Phytophthora cinnamomi rands

dc.contributor.authorChavez M.I.
dc.contributor.authorSoto M.
dc.contributor.authorCimino F.A.
dc.contributor.authorOlea A.F.
dc.contributor.authorEspinoza L.
dc.contributor.authorDíaz K.
dc.contributor.authorTaborga L.
dc.date.accessioned2020-09-02T22:14:51Z
dc.date.available2020-09-02T22:14:51Z
dc.date.issued2018
dc.identifier10.3390/ijms19061601
dc.identifier.citation19, 6, -
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4016
dc.descriptionA series of new and known geranylated phenol/methoxyphenol derivatives has been tested in vitro as inhibitor agents of mycelial growth of Phytophthora cinnamomi. The activity of tested compounds is correlated with the nature, number, and position of the substituent group on the aromatic ring. Results indicate that the most active geranylated derivatives are those having two hydroxyl groups (or one –OH and one –OCH3) attached to the aromatic ring. Interestingly, these derivatives are as active as Metalaxil®;, a commonly used commercial fungicide. Thus, our results suggest that some of these compounds might be of agricultural interest due to their potential use as fungicides against P. cinnamomi. The effect of structure on fungicide activity is discussed in terms of electronic distribution on both the aromatic ring and side geranyl chain. All tested compounds have been synthesized by direct coupling of geraniol and the respective phenol. Interestingly, new digeranylated derivatives were obtained by increasing the reaction time. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntifungal activity
dc.subjectFungicide
dc.subjectGeranylated phenols
dc.subjectOomycetes
dc.subjectPhytophthora cinnamomi
dc.subject(e) 2 (3,7 dimethylocta 2,6 dienyl) 3,4,5 trimethoxyphenol
dc.subject(e) 2 (3,7 dimethylocta 2,6 dienyl) 6 methoxyphenol
dc.subject(e) 3 (3,7 dimethylocta 2,6 dienyl) 2 methoxyphenol
dc.subject(e) 3 (3,7 dimethylocta 2,6 dienyl)benzene 1,2 diol
dc.subject(e) 4 (3,7 dimethylocta 2,6 dienyl) 2,3 dimethoxyphenol
dc.subject(e) 4 (3,7 dimethylocta 2,6 dienyl)benzene 1,2 diol
dc.subject(e) 4 (3,7 dimethylocta 2,6 dienyl)benzene 1,3 diol
dc.subject(e) 5 (3,7 dimethylocta 2,6 dienyl) 2 methoxyphenol
dc.subject(e) 5 (3,7 dimethylocta 2,6 dienyl)benzene 1,2,4 triol
dc.subject(e) 6 (3,7 dimethylocta 2,6 dienyl) 2,3 dimethoxyphenol
dc.subject2,4 bis((e) 3,7 dimethylocta 2,6 dienyl)benzene 1,3 diol
dc.subject2,6 bis((e) 3,7 dimethylocta 2,6 dienyl) 3,4,5 trimetoxyphenol
dc.subject4,5 bis((e) 3,7 dimethylocta 2,6 d ienyl) 2 methoxyphenol
dc.subject4,5 bis((e) 3,7 dimethylocta 2,6 dienyl)benzene 1,2 diol
dc.subject4,6 bis((e) 3,7 dimethylocta 2,6 dienyl)benzene 1,3 diol
dc.subjectcatechol
dc.subjectgeraniol
dc.subjectgeranylated phenol
dc.subjectphenol
dc.subjectunclassified drug
dc.subjectantifungal agent
dc.subjectphenol derivative
dc.subjectantifungal activity
dc.subjectArticle
dc.subjectBotrytis cinerea
dc.subjectcontrolled study
dc.subjectgrowth inhibition
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectPhytophthora cinnamomi
dc.subjectchemistry
dc.subjectgrowth, development and aging
dc.subjectPhytophthora
dc.subjectsynthesis
dc.subjectAntifungal Agents
dc.subjectPhenols
dc.subjectPhytophthora
dc.titleIn vitro antifungal activity of new and known geranylated phenols against Phytophthora cinnamomi rands
dc.typeArticle


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