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No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine

dc.contributor.authorCernuda-Morollón E.
dc.contributor.authorRiesco N.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorSerrano-Pertierra E.
dc.contributor.authorGarcía-Cabo C.
dc.contributor.authorPascual J.
dc.date.accessioned2020-09-02T22:14:47Z
dc.date.available2020-09-02T22:14:47Z
dc.date.issued2016
dc.identifier10.1111/head.12949
dc.identifier.citation56, 9, 1448-1454
dc.identifier.issn00178748
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3989
dc.descriptionObjective: To determine total pituitary adenylate cyclase activating polypeptide (PACAP) in peripheral blood as a potential marker of the activation of the parasympathetic arm of the trigemino-vascular system in chronic migraine (CM) in a case-control study. Methods: Women older than 17 and diagnosed as CM were recruited. Healthy women with no headache history and women with episodic migraine (EM) served as control groups. Total PACAP and vasoactive intestinal peptide (VIP) levels were determined in blood samples obtained from the right antecubital vein by ELISA outside a migraine attack and having taken no symptomatic medication the day before. Results: We assessed serum samples from 86 women with CM, 32 healthy women, and 35 women with EM. There were no differences in PACAP levels in CM patients (109.8 ± 43.8, 97.4 [32.5–253.1] pg/mL), controls (108.7 ± 43.0, 98.7 [50.7–197.3] pg/mL), or EM patients (98.8 ± 34.3, 94.2 [52.0–190.7] pg/mL). VIP levels were significantly increased (P =.027) in CM as compared to control healthy women (136.0 ± 111.5 pg/mL; 103.1 [20.5–534.0] pg/mL vs 88.6 ± 61.0 pg/mL; 66.0 [21.1–256.1]) and EM patients (103.0 ± 56.7 pg/mL; 103.5 [15.2–263.0] pg/mL). In the range of this study variables such as age, CM duration, the presence of aura, analgesic overuse, depression, fibromyalgia, vascular risk factors, history of triptan consumption or kind of preventative treatment did not significantly influence PACAP or VIP levels. Conclusion: In contrast to VIP, interictal PACAP level measured in peripheral blood does not seem to be a biomarker reflecting parasympathetic activation in CM. © 2016 American Headache Society
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.subjectchronic migraine
dc.subjectpituitary adenylate cyclase activating polypeptide
dc.subjecttrigemino-vascular system
dc.subjectvasoactive intestinal peptide
dc.subjectanalgesic agent
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectbiological marker
dc.subjectcandesartan
dc.subjecthypophysis adenylate cyclase activating polypeptide
dc.subjectlisinopril
dc.subjectserotonin uptake inhibitor
dc.subjecttopiramate
dc.subjectvalproic acid
dc.subjectvasoactive intestinal polypeptide
dc.subjectzonisamide
dc.subjectADCYAP1 protein, human
dc.subjectbiological marker
dc.subjecthypophysis adenylate cyclase activating polypeptide
dc.subjectadult
dc.subjectage
dc.subjectArticle
dc.subjectasthma
dc.subjectcase control study
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdisease duration
dc.subjectdrug misuse
dc.subjectepilepsy
dc.subjectepisodic migraine
dc.subjectfemale
dc.subjectfibromyalgia
dc.subjecthuman
dc.subjecthypercholesterolemia
dc.subjecthypertension
dc.subjectmajor clinical study
dc.subjectmigraine aura
dc.subjectmonotherapy
dc.subjectobesity
dc.subjectpalliative therapy
dc.subjectpriority journal
dc.subjectprophylaxis
dc.subjecttherapy
dc.subjecttransformed migraine
dc.subjectadolescent
dc.subjectblood
dc.subjectblood analysis
dc.subjectcomorbidity
dc.subjectcomplication
dc.subjectenzyme linked immunosorbent assay
dc.subjectmiddle aged
dc.subjectMigraine Disorders
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectBlood Chemical Analysis
dc.subjectCase-Control Studies
dc.subjectComorbidity
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectMigraine Disorders
dc.subjectPituitary Adenylate Cyclase-Activating Polypeptide
dc.subjectYoung Adult
dc.titleNo Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine
dc.typeArticle


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