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Caffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling

dc.contributor.authorCechella J.L.
dc.contributor.authorLeite M.R.
dc.contributor.authorDa Rocha J.T.
dc.contributor.authorDobrachinski F.
dc.contributor.authorGai B.M.
dc.contributor.authorSoares F.A.A.
dc.contributor.authorBresciani G.
dc.contributor.authorRoyes L.F.F.
dc.contributor.authorZeni G.
dc.date.accessioned2020-09-02T22:14:47Z
dc.date.available2020-09-02T22:14:47Z
dc.date.issued2014
dc.identifier10.1016/j.cbi.2014.09.001
dc.identifier.citation223, , 95-101
dc.identifier.issn00092797
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3984
dc.descriptionThe cognitive function decline is closely related with brain changes generated by age. The ability of caffeine and exercise to prevent memory impairment has been reported in animal models and humans. The purpose of the present study was to investigate whether swimming exercise and caffeine administration enhance memory in middle-aged Wistar rats. Male Wistar rats (18 months) received caffeine at a dose of 30 mg/kg, 5 days per week by a period of 4 weeks. Animals were subjected to swimming training with a workload (3% of body weight, 20 min per day for 4 weeks). After 4 weeks, the object recognition test (ORT) and the object location test (OLT) were performed. The results of this study demonstrated that caffeine suppressed exercise-enhanced long-term (ORT) and spatial (OLT) memory in middle-aged and this effect may be related to a decrease in hippocampal p-CREB signaling. This study also provided evidence that the effects of this protocol on memory were not accompanied by alterations in the levels of activated Akt. The [3H] glutamate uptake was reduced in hippocampus of rats administered with caffeine and submitted to swimming protocol. © 2014 Elsevier Ireland Ltd. All rights reserved.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectAkt
dc.subjectCaffeine
dc.subjectCREB
dc.subjectExercise
dc.subjectMemory
dc.subjectMiddle-aged
dc.subjectcaffeine
dc.subjectcyclic AMP responsive element binding protein
dc.subjectprotein kinase B
dc.subjectcaffeine
dc.subjectcyclic AMP responsive element binding protein
dc.subjectglutamic acid
dc.subjectprotein kinase B
dc.subjectadult
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectexercise
dc.subjectexperimental test
dc.subjectlocation memory
dc.subjectlong term memory
dc.subjectmale
dc.subjectmemory
dc.subjectmiddle aged
dc.subjectnonhuman
dc.subjectnovel object recognition test
dc.subjectobject location test
dc.subjectrat
dc.subjectshort term memory
dc.subjectsignal transduction
dc.subjectswimming
dc.subjectworkload
dc.subjectaging
dc.subjectanimal
dc.subjectdrug effects
dc.subjectexercise
dc.subjecthippocampus
dc.subjectlong term memory
dc.subjectMemory Disorders
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectpsychology
dc.subjectspatial memory
dc.subjectWistar rat
dc.subjectAging
dc.subjectAnimals
dc.subjectCaffeine
dc.subjectCyclic AMP Response Element-Binding Protein
dc.subjectGlutamic Acid
dc.subjectHippocampus
dc.subjectMale
dc.subjectMemory Disorders
dc.subjectMemory, Long-Term
dc.subjectPhysical Exertion
dc.subjectProto-Oncogene Proteins c-akt
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSignal Transduction
dc.subjectSpatial Memory
dc.subjectSwimming
dc.titleCaffeine suppresses exercise-enhanced long-term and location memory in middle-aged rats: Involvement of hippocampal Akt and CREB signaling
dc.typeArticle


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