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Steps per Day and Arterial Stiffness: Systematic Review and Meta-Analysis

dc.contributor.authorCavero-Redondo I.
dc.contributor.authorTudor-Locke C.
dc.contributor.authorÁlvarez-Bueno C.
dc.contributor.authorCunha P.G.
dc.contributor.authorAguiar E.J.
dc.contributor.authorMartínez-Vizcaíno V.
dc.date.accessioned2020-09-02T22:14:46Z
dc.date.available2020-09-02T22:14:46Z
dc.date.issued2019
dc.identifier10.1161/HYPERTENSIONAHA.118.11987
dc.identifier.citation73, 2, 350-363
dc.identifier.issn0194911X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3975
dc.descriptionArterial stiffness has emerged as an independent predictor of cardiovascular morbidity and mortality. Furthermore, objectively monitored steps per day is widely perceived to be beneficial for controlling health risk factors, and for preventing morbidity and mortality. The aim of this review was to determine the relationship between steps per day and arterial stiffness, as measured by its reference standard, pulse wave velocity (PWv). We systematically searched for cross-sectional data from studies addressing the association between steps per day and PWv. The DerSimonian and Laird method was used to compute pooled estimates of correlation and their respective 95% CI. Additionally, we used a regression model to estimate the pooled mean PWv by categories of physical activity behavior: sedentary <5000; low active 5000 to 7499; active 7500 to 9999; and highly active 10 000+. Twenty published studies were included in the systematic review, but only 10 studies in adults and older adults could be incorporated in the meta-analysis. Steps per day was inversely correlated with arterial stiffness measured by PWv in adults and older adults (r=-0.18; 95% CI: -0.27 to -0.10; P<0.001), with substantial heterogeneity (I2=77.9%; P<0.001). The regression model showed that the pooled PWv was lower with a corresponding higher level of steps per day, influenced primarily by low PWv values for the highly active lifestyle category (Ptrend=0.005). This systematic review and meta-analysis demonstrates a clinically meaningful association between objectively monitored steps per day and PWv, an accepted indicator of arterial stiffness and an early subclinical risk factor for cardiovascular disease. Systematic Review Registration - PROSPERO CRD42018088228. © 2018 American Heart Association, Inc.
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.subjectadult
dc.subjectcardiovascular disease
dc.subjectexercise
dc.subjectpulse wave analysis
dc.subjectvascular stiffness
dc.subjectarterial stiffness
dc.subjectautism
dc.subjectchildhood obesity
dc.subjectchronic obstructive lung disease
dc.subjecthuman
dc.subjecthypertension
dc.subjectlifestyle
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectphysical activity
dc.subjectpractice guideline
dc.subjectpriority journal
dc.subjectpulse wave
dc.subjectReview
dc.subjectsedentary lifestyle
dc.subjectstep count
dc.subjectsystematic review
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectcardiovascular disease
dc.subjectchild
dc.subjectexercise
dc.subjectmeta analysis
dc.subjectmiddle aged
dc.subjectrisk factor
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectCardiovascular Diseases
dc.subjectChild
dc.subjectExercise
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectPulse Wave Analysis
dc.subjectRisk Factors
dc.subjectVascular Stiffness
dc.subjectYoung Adult
dc.titleSteps per Day and Arterial Stiffness: Systematic Review and Meta-Analysis
dc.typeReview


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