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Lifetime predictors of stroke in subjects without a diagnosis of hypertension: The aerobics center longitudinal study

dc.contributor.authorCavero-Redondo I.
dc.contributor.authorSui X.
dc.contributor.authorBlair S.N.
dc.contributor.authorLavie C.J.
dc.contributor.authorÁlvarez-Bueno C.
dc.contributor.authorMartínez-Vizcaíno V.
dc.date.accessioned2020-09-02T22:14:46Z
dc.date.available2020-09-02T22:14:46Z
dc.date.issued2019
dc.identifier10.2147/NDT.S193842
dc.identifier.citation15, , 849-856
dc.identifier.issn11766328
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3974
dc.descriptionBackground and purpose: Although several studies have assessed the importance of traditional risk factors in predicting stroke, none have concurrently addressed the stroke-predicting ability of these risk factors across the lifespan of subjects without a hypertension (HTN) diagnosis. Thus, this study aimed to assess the importance of blood-pressure-related risk indicators, cardiorespiratory fitness (CRF), weight status, diabetes mellitus (DM), and lifestyle factors as predictors of stroke in different stages of life among non-hypertensive subjects. Materials and methods: This study was a long-term follow-up study including 33,254 men and 10,598 women from the Aerobics Center Longitudinal Study (ACLS) who were 18-100 years old and did not have a HTN diagnosis at baseline. Logistic regression models were constructed using forward selection procedures for each age category, with stroke occurrence as the dependent variable, and pulse pressure (PP), mean arterial pressure (MAP), systolic blood pressure (SBP), smoking status, CRF, drinking behavior, DM status, and weight status as potential predictors. Results: In total, 507 subjects had a stroke during an average follow-up period of 17 years (range=1-34 years). Logistic regression models showed that MAP values (P=0.043) in those aged 19-39 years; SBP (P<0.001), CRF (P=0.001), weight status (P=0.005), and alcohol consumption (P=0.001) in those 40-60 years old; and CRF (P=0.002), weight status (P=0.005), and DM status (P=0.037) in those over 60 years old were predictors of stroke. Conclusion: These findings suggest that, among individuals without a baseline HTN diagnosis, classic modifiable risk factors for stroke change across different stages of life. © 2019 Cavero-Redondo et al.
dc.language.isoen
dc.publisherDove Medical Press Ltd.
dc.subjectCerebrovascular disease
dc.subjectCohort study
dc.subjectIncidence
dc.subjectRisk factors
dc.subjectStroke
dc.subjectadult
dc.subjectaged
dc.subjectalcohol consumption
dc.subjectArticle
dc.subjectbody weight
dc.subjectcardiorespiratory fitness
dc.subjectcerebrovascular accident
dc.subjectdiabetes mellitus
dc.subjectdrinking behavior
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthypertension
dc.subjectlifestyle
dc.subjectlongitudinal study
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectpopulation risk
dc.subjectprospective study
dc.subjectpulse pressure
dc.subjectrisk factor
dc.subjectsmoking
dc.subjectsystolic blood pressure
dc.titleLifetime predictors of stroke in subjects without a diagnosis of hypertension: The aerobics center longitudinal study
dc.typeArticle


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