Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
Autor
Cavero-Redondo I.
Soriano-Cano A.
Álvarez-Bueno C.
Cunha P.G.
Martínez-Hortelano J.A.
Garrido-Miguel M.
Berlanga-Macías C.
Martínez-Vizcaíno V.
Resumen
predictors of atherosclerotic-related disorders. This study aimed to estimate the relationship between advanced glycation end products indicated by skin autofluorescence levels and the risk of cardiovascular and all-cause mortality based on data from observational studies. Methods and Results-—We systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Web of Science databases from their inceptions until November 2017 for observational studies addressing the association of advanced glycation end products by skin autofluorescence levels with cardiovascular and all-cause mortality. The DerSimonian and Laird random-effects method was used to compute pooled estimates of hazard ratios and their respective 95% confidence intervals for the risk of cardiovascular and all-cause mortality associated with levels of advanced glycation end products by skin autofluorescence. Ten published studies were included in the systematic review and meta-analysis. Higher skin autofluorescence levels were significantly associated with a higher pooled risk estimate for cardiovascular mortality (hazard ratio: 2.06; 95% confidence interval, 1.58–2.67), which might not be important to moderate heterogeneity (I2=34.7%; P=0.163), and for all-cause mortality (hazard ratio: 1.91; 95% confidence interval, 1.42–2.56) with substantial heterogeneity (I2=60.8%; P=0.0.18). Conclusions-—Our data suggest that skin autofluorescence levels could be considered predictors of all-cause mortality and cardiovascular mortality in patients at high and very high risk. © 2018 The Authors.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Glycated haemoglobin A1c as a risk factor of cardiovascular outcomes and all-cause mortality in diabetic and non-diabetic populations: A systematic review and meta-analysis (2020)
Cavero-Redondo I.; Peleteiro B.; Álvarez-Bueno C.; Rodriguez-Artalejo F.; Martínez-Vizcaíno V. (BMJ Publishing Group, 2017) -
Review
Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population: A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women (2020)
García-Hermoso A.; Cavero-Redondo I.; Ramírez-Vélez R.; Ruiz J.R.; Ortega F.B.; Lee D.-C.; Martínez-Vizcaíno V. (W.B. Saunders, 2018) -
Review
Role of Physical Activity and Fitness in the Characterization and Prognosis of the Metabolically Healthy Obesity Phenotype: A Systematic Review and Meta-analysis (2020)
Ortega F.B.; Cadenas-Sanchez C.; Migueles J.H.; Labayen I.; Ruiz J.R.; Sui X.; Blair S.N.; Martínez-Vizcaino V.; Lavie C.J. (W.B. Saunders, 2018)