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ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population

dc.contributor.authorCastro-Santos P.
dc.contributor.authorMoro-García M.A.
dc.contributor.authorMarcos-Fernández R.
dc.contributor.authorAlonso-Arias R.
dc.contributor.authorDíaz-Peña R.
dc.date.accessioned2020-09-02T22:14:21Z
dc.date.available2020-09-02T22:14:21Z
dc.date.issued2017
dc.identifier10.1177/1753425917716527
dc.identifier.citation23, 5, 476-481
dc.identifier.issn17534259
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3966
dc.descriptionLarge genome-wide analysis studies (GWAS) and meta-analyses have dramatically increased our knowledge of the genetic risk factors of inflammatory bowel disease (IBD), identifying at least 163 loci. The endoplasmic reticulum aminopeptidase-2 (ERAP2) gene has been reported as a potential candidate gene for IBD. GWAS have also shown the potential associations between ERAP single nucleotide polymorphisms (SNP) loci and susceptibility to several autoimmune diseases, and ERAP1 and ERAP2 polymorphisms are related to HLA class I-associated diseases, including ankylosing spondylitis and Behçet's disease. Interestingly, these associations were confined to individuals carrying HLA class I-risk alleles. The aim of this study was to investigate the association of ERAP1 and ERAP2 SNPs with IBD in a Spanish population, analysing their possible interaction with specific HLA-C alleles to IBD susceptibility. A total of 367 individuals were divided into 216 IBD cases and 151 controls. SNP genotyping was performed using TaqMan® genotyping assays, whereas HLA-C typing was analysed by sequence-specific oligonucleotide probing. Herein, we report an association of the ERAP1 SNP rs30187 with the HLA-C∗07 allele. The existence of shared inflammatory pathways in immunologically related diseases together with the understanding of ERAP1 function may offer clues to novel treatment strategies. © SAGE Publications.
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.subjectCrohn's disease
dc.subjectERAP1
dc.subjectHLA-C
dc.subjectinflammatory bowel disease
dc.subjectulcerative colitis
dc.subjectaminopeptidase
dc.subjectERAP1 protein, human
dc.subjectERAP2 protein, human
dc.subjectHLA C antigen
dc.subjectminor histocompatibility antigen
dc.subjectantigen presentation
dc.subjectbiological model
dc.subjectcytotoxicity
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic association study
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectgenotype
dc.subjecthuman
dc.subjectinflammatory bowel disease
dc.subjectmale
dc.subjectmolecular mimicry
dc.subjectrisk
dc.subjectsingle nucleotide polymorphism
dc.subjectSpain
dc.subjectAminopeptidases
dc.subjectAntigen Presentation
dc.subjectCytotoxicity, Immunologic
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHLA-C Antigens
dc.subjectHumans
dc.subjectInflammatory Bowel Diseases
dc.subjectMale
dc.subjectMinor Histocompatibility Antigens
dc.subjectModels, Immunological
dc.subjectMolecular Mimicry
dc.subjectPolymorphism, Single Nucleotide
dc.subjectRisk
dc.subjectSpain
dc.titleERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population
dc.typeArticle


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