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Genomics, proteomics and metabolomics: Their emerging roles in the discovery and validation of rheumatoid arthritis biomarkers

dc.contributor.authorCastro-Santos P.
dc.contributor.authorLaborde C.M.
dc.contributor.authorDíaz-Peña R.
dc.date.accessioned2020-09-02T22:14:21Z
dc.date.available2020-09-02T22:14:21Z
dc.date.issued2015
dc.identifier.citation33, 2, 279-286
dc.identifier.issn0392856X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3965
dc.descriptionRheumatoid arthritis (RA) is an autoimmune inflammatory rheumatic disease which affects several organs and tissues, predominantly the synovial joints. Despite major advances, the aetiology of this disease is not completely understood. Although several biomarkers are routinely used in RA management and some of them can be detected even prior to the onset of the clinical disease, there is a high demand for novel biomarkers to further improve the early diagnosis of RA. The '-omics' techniques that have emerged and have been developed in recent years have allowed researchers to improve their knowledge of the aetiopathology of RA. At the same time, advances in screening technologies offer an excellent opportunity to find new biomarkers potentially useful for early diagnosis, stratification of patients, and even prediction of a better response to a specific therapy. This review describes what is known about the methodologies used in the discovery of novel biomarkers in RA, along with the findings of these methodologies, with specific attention to recent advances in the fields of genomics, proteomics and metabolomics. © Clinical and Experimental Rheumatology 2015.
dc.language.isoen
dc.publisherClinical and Experimental Rheumatology S.A.S.
dc.subjectGenomics
dc.subjectMetabolomics
dc.subjectProteomics
dc.subjectRheumatoid arthritis
dc.subjectbiological marker
dc.subjectmicroRNA
dc.subjectbiological marker
dc.subjectgenetic marker
dc.subjectblood analysis
dc.subjectDNA methylation
dc.subjectepigenetics
dc.subjectgel electrophoresis
dc.subjectgene locus
dc.subjectgenetic association
dc.subjectgenetic risk
dc.subjectgenomics
dc.subjecthistone modification
dc.subjecthuman
dc.subjectliquid chromatography
dc.subjectmajor histocompatibility complex
dc.subjectmetabolomics
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectproteomics
dc.subjectReview
dc.subjectrheumatoid arthritis
dc.subjectsynovial fluid
dc.subjecturinalysis
dc.subjectanimal
dc.subjectArthritis, Rheumatoid
dc.subjectearly diagnosis
dc.subjectgenetic marker
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectpredictive value
dc.subjectprocedures
dc.subjectprognosis
dc.subjectAnimals
dc.subjectArthritis, Rheumatoid
dc.subjectBiological Markers
dc.subjectEarly Diagnosis
dc.subjectGenetic Markers
dc.subjectGenetic Predisposition to Disease
dc.subjectGenomics
dc.subjectHumans
dc.subjectMetabolomics
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectProteomics
dc.titleGenomics, proteomics and metabolomics: Their emerging roles in the discovery and validation of rheumatoid arthritis biomarkers
dc.typeReview


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