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Genetics of ankylosing spondylitis [Genética, HLA-B27 y espondilitis anquilosante: 40 años]

dc.contributor.authorCastro-Santos P.
dc.contributor.authorGutiérrez M.A.
dc.contributor.authorDíaz-Peña R.
dc.date.accessioned2020-09-02T22:14:21Z
dc.date.available2020-09-02T22:14:21Z
dc.date.issued2014
dc.identifier10.4067/S0034-98872014000900011
dc.identifier.citation142, 9, 1165-1173
dc.identifier.issn00349887
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3964
dc.descriptionAnkylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients’ quality of life. © 2014, Sociedad Medica de Santiago. All rights reserved.
dc.language.isoes
dc.publisherSociedad Medica de Santiago
dc.subjectAnkylosing
dc.subjectGenetic predisposition to disease
dc.subjectHLA-B27 antigen
dc.subjectSpondylitis
dc.subjectHLA B27 antigen
dc.subjectankylosing spondylitis
dc.subjectfemale
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjecthuman
dc.subjectmale
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectHLA-B27 Antigen
dc.subjectHumans
dc.subjectMale
dc.subjectSpondylitis, Ankylosing
dc.titleGenetics of ankylosing spondylitis [Genética, HLA-B27 y espondilitis anquilosante: 40 años]
dc.typeArticle


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