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Genetics of rheumatoid arthritis: A new boost is needed in Latin American populations

dc.contributor.authorCastro-Santos P.
dc.contributor.authorDíaz-Peña R.
dc.date.accessioned2020-09-02T22:14:20Z
dc.date.available2020-09-02T22:14:20Z
dc.date.issued2016
dc.identifier10.1016/j.rbre.2015.10.004
dc.identifier.citation56, 2, 171-177
dc.identifier.issn04825004
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3962
dc.descriptionRheumatoid arthritis (RA) is an autoimmune inflammatory rheumatic disease which affects several organs and tissue, predominantly the synovial joints. Like many other autoimmune diseases, RA is a complex disease, where genetic variants, environmental factors and random events interact to trigger pathological pathways. Genetic implication in RA is evident, and recent advances have expanded our knowledge about the genetic factors that contribute to RA. An exponential increment in the number of genes associated with the disease has been described, mainly through gene wide screen studies (GWAS) involving international consortia with large patient cohorts. However, there are a few studies on Latin American populations. This article describes what is known about the RA genetics, the future that is emerging, and how this will develop a more personalized approach for the treatment of the disease. Latin American RA patients cannot be excluded from this final aim, and a higher collaboration with the international consortia may be needed for a better knowledge of the genetic profile of patients from this origin. © 2015 Elsevier Editora Ltda. All rights reserved.
dc.language.isoen
dc.publisherElsevier Editora Ltda
dc.subjectGenetic susceptibility
dc.subjectGenome wide association studies
dc.subjectHLA
dc.subjectRheumatoid arthritis
dc.subjectSingle nucleotide polymorphism
dc.subjectautoimmune disease
dc.subjectenvironmental factor
dc.subjectgenetic association
dc.subjectgenetic variability
dc.subjectheredity
dc.subjecthuman
dc.subjectinflammatory disease
dc.subjectpathophysiology
dc.subjectReview
dc.subjectrheumatic disease
dc.subjectrheumatoid arthritis
dc.subjectSouth and Central America
dc.subjectgenetic predisposition
dc.subjectgenetic variation
dc.subjectgenetics
dc.subjectrheumatoid arthritis
dc.subjectAmerican
dc.subjectArticle
dc.subjectgenetic association
dc.subjectgenetic disorder
dc.subjectgenetic risk
dc.subjectgenetic screening
dc.subjectgenetic susceptibility
dc.subjecthuman genetics
dc.subjectinternational cooperation
dc.subjectLatin American
dc.subjectpersonalized medicine
dc.subjectpopulation genetics
dc.subjectpopulation research
dc.subjectArthritis, Rheumatoid
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Variation
dc.subjectHumans
dc.subjectLatin America
dc.titleGenetics of rheumatoid arthritis: A new boost is needed in Latin American populations
dc.typeShort Survey


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