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Effects of a single high dose of Chlorpyrifos in long-term feeding, ethanol consumption and ethanol preference in male Wistar rats with a previous history of continued ethanol drinking

dc.contributor.authorCarvajal F.
dc.contributor.authorSanchez-Amate M.C.
dc.contributor.authorLerma-Cabrera J.M.
dc.contributor.authorCubero I.
dc.date.accessioned2020-09-02T22:14:17Z
dc.date.available2020-09-02T22:14:17Z
dc.date.issued2014
dc.identifier10.2131/jts.39.425
dc.identifier.citation39, 3, 425-435
dc.identifier.issn18803989
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3941
dc.descriptionChlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks. We have previously reported reduced voluntary ethanol drinking 8 weeks post-CPF administration in Wistar rats when AChE activity was almost completely recovered. Additionally, the OPs disrupt the functioning of certain neurochemical systems and modify the formation and/or degradation of some neuropeptides with a known role in regulating voluntary consumption of alcohol. Moreover, chronic ethanol intake significantly alters the regional expression of some of these neurochemical systems. Thus, the present study explored whether a previous history with ethanol consumption modify the disturbance in the voluntary ethanol consumption induced by CPF administration. For this aim, we measured ethanol consumption in increasing concentrations (8%, 15% and 20% w/v) from 4 days to 8 weeks following a single dose of CPF. Two experiments were carried out; experiment 1 was conducted in ethanol-naïve rats and experiment 2, in animals with a previous history of ethanol drinking before CPF administration. Additionally, food and body weight measures were collected. We report here a significant increase in ethanol consumption and preference at high ethanol concentrations (15% and 20%) in CPF-treated animals with a previous history of ethanol consumption (experiment 1) and a long-lasting increase in food intake both in ethanol-exposed (experiment 1) and ethanol-naïve CPF-treated rats (experiment 2). Present data are discussed under the interesting idea that CPF targets neurobiological pathways critically involved with ethanol consumption. Additionally, we conclude that CPF effects on voluntary ethanol consumption are ethanol-experience dependent.
dc.language.isoen
dc.publisherJapanese Society of Toxicology
dc.subjectChlorpyrifos
dc.subjectEthanol drinking
dc.subjectFood consumption
dc.subjectOrganophosphates
dc.subjectacetylcholinesterase
dc.subjectchlorpyrifos
dc.subjectalcohol consumption
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectfood intake
dc.subjectfood preference
dc.subjectmale
dc.subjectneurotransmission
dc.subjectnonhuman
dc.subjectrat
dc.subjecttoxicity testing
dc.subjectAcetylcholinesterase
dc.subjectAlcohol Drinking
dc.subjectAlcoholism
dc.subjectAnimals
dc.subjectBrain
dc.subjectChlorpyrifos
dc.subjectEating
dc.subjectInjections
dc.subjectMale
dc.subjectNeuropeptides
dc.subjectOrganophosphorus Compounds
dc.subjectPesticides
dc.subjectRats
dc.subjectRats, Wistar
dc.titleEffects of a single high dose of Chlorpyrifos in long-term feeding, ethanol consumption and ethanol preference in male Wistar rats with a previous history of continued ethanol drinking
dc.typeArticle


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