Mostrar el registro sencillo del ítem

A single high dose of chlorpyrifos reduces long-term basal C-fos expression in the rat arcuate hypothalamic nucleus [La Administración de una Dosis Aguda de Clorpirifós Reduce a Largo Plazo la Expresión Basal de C-Fos en el Núcleo Arqueado del Hipotálamo]

dc.contributor.authorCarvajal F.
dc.contributor.authorLerma-Cabrera J.M.
dc.contributor.authorSánchez-Amate M.C.
dc.contributor.authorCubero I.
dc.date.accessioned2020-09-02T22:14:17Z
dc.date.available2020-09-02T22:14:17Z
dc.date.issued2014
dc.identifier10.4067/S0717-95022014000100015
dc.identifier.citation32, 1, 90-96
dc.identifier.issn07179367
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3940
dc.descriptionChlorpyrifos (CPF) is an organophosphate compound used worldwide as a pesticide in agriculture that, after subcutaneous injection, keeps acetylcholinesterase (AChE) activity inhibited within an organism for months. Ample clinical and experimental evidence shows that CPF exposure induces relevant and persistent neurobehavioral deficits in humans and animals, even after one single episode/injection. Additionally, clinical and epidemiological studies evidence that a significant percentage (60%) of Gulf War veterans as well as agricultural workers suffering from acute OP intoxication may have developed intolerance to nicotine and ethanolcontaining beverages. Consistent with it, administration of a single high dose of CPF to adult Wistar rats elicited long-lasting reduced voluntary ethanol drinking and increased sedation to ethanol without evidence of altered ethanol metabolism, which indicates that CPFethanol neurobiological interactions may exist. In this study, we explore whether CPF exposure induces significant disturbances in basal and/or ethanol-evoked neural activity in a set of cholinoceptive brain regions critically involved with neurobiological responses to ethanol. For this aim, brain regional c-fos expression in response to acute ethanol (1.5 or 3.0 g/kg, i.p.) or saline was assessed in adult male Wistar rats previously injected with either a single high dose of CPF (250 mg/kg, sc) or vehicle. We found that CPF administration reduces long-term basal, but not ethanol-evoked, c-fos expression in the arcuate hypothalamic nucleus. Because independent brain pathways may modulate acute responses to ethanol and voluntary ethanol consumption, we do not rule out the contribution of basal neural disturbances observed in the Arc to CPF-elicited ethanol avoidance.
dc.language.isoen
dc.language.isoes
dc.publisherUniversidad de la Frontera
dc.subjectArcuate hypothalamic nucleus
dc.subjectC-fos expression
dc.subjectChlorpyrifos
dc.subjectEthanol consumption
dc.subjectOrganophosphates
dc.titleA single high dose of chlorpyrifos reduces long-term basal C-fos expression in the rat arcuate hypothalamic nucleus [La Administración de una Dosis Aguda de Clorpirifós Reduce a Largo Plazo la Expresión Basal de C-Fos en el Núcleo Arqueado del Hipotálamo]
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84900866528.pdf
Tamaño:
2.948Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem