Mostrar el registro sencillo del ítem

Astrocytes as the main players in primary degenerative disorders of the human central nervous system

dc.contributor.authorCapani F.
dc.contributor.authorQuarracino C.
dc.contributor.authorCaccuri R.
dc.contributor.authorSica R.E.P.
dc.date.accessioned2020-09-02T22:14:11Z
dc.date.available2020-09-02T22:14:11Z
dc.date.issued2016
dc.identifier10.3389/fnagi.2016.00045
dc.identifier.citation8, MAR, -
dc.identifier.issn16634365
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3911
dc.descriptionAlong the last years it has been demonstrated that non-neural cells play a major role in the pathogenesis of the primary degenerative disorders (PDDs) of the human central nervous system. Among them, astrocytes coordinate and participate in many different and complex metabolic processes, in close interaction with neurons. Moreover, increasing experimental evidence hints an early astrocytic dysfunction in these diseases. In this mini review we summarize the astrocytic behavior in PDDs, with special consideration to the experimental observations where astrocytic pathology precedes the development of neuronal dysfunction. We also suggest a different approach that could be consider in human investigations in Alzheimer's and Parkinson's disease. We believe that the study of PDDs with human brain samples may hold the key of a paradigmatic physiopathological process in which astrocytes might be the main players. © 2016 Capani, Quarracino, Caccuri and Sica.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAstrocytes
dc.subjectHuman central nervous system
dc.subjectNeurodegeneration
dc.subjectPrimary astrocytic degeneration
dc.subjectPrimary degenerative disorders
dc.subjectAlzheimer disease
dc.subjectamyotrophic lateral sclerosis
dc.subjectastrocyte
dc.subjectbehavior
dc.subjectcentral nervous system
dc.subjectdegenerative disease
dc.subjectfrontotemporal dementia
dc.subjecthuman
dc.subjecthuman cell
dc.subjectHuntington chorea
dc.subjectmajor depression
dc.subjectmouse
dc.subjectnerve cell
dc.subjectnerve degeneration
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectpathogenesis
dc.subjectschizophrenia
dc.subjectShort Survey
dc.subjectspinocerebellar degeneration
dc.titleAstrocytes as the main players in primary degenerative disorders of the human central nervous system
dc.typeShort Survey


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84964670013.pdf
Tamaño:
2.619Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem