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In vivo biocompatibility of the PLGA microparticles in parotid gland

dc.contributor.authorCantín M.
dc.contributor.authorMiranda P.
dc.contributor.authorGaldames I.S.
dc.contributor.authorZavando D.
dc.contributor.authorArenas P.
dc.contributor.authorVelásquez L.
dc.contributor.authorVilos C.
dc.date.accessioned2020-09-02T22:14:10Z
dc.date.available2020-09-02T22:14:10Z
dc.date.issued2013
dc.identifier.citation6, 11, 2412-2418
dc.identifier.issn19362625
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3903
dc.descriptionPoly(lactic-co-glycolic acid) (PLGA) microparticles are used in various disorders for the controlled or sustained release of drugs, with the management of salivary gland pathologies possible using this technology. There is no record of the response to such microparticles in the glandular parenchyma. The purpose of this study was to assess the morphological changes in the parotid gland when injected with a single dose of PLGA microparticles. We used 12 adult female Sprague Dawley rats (Rattus norvegicus) that were injected into their right parotid gland with sterile vehicle solution (G1, n=4), 0.5 mg PLGA microparticles (G2, n=4), and 0.75 mg PLGA microparticles (G3, n=4); the microparticles were dissolved in a sterile vehicle solution. The intercalar and striated ducts lumen, the thickness of the acini and the histology aspect in terms of the parenchyma organization, cell morphology of acini and duct system, the presence of polymeric residues, and inflammatory response were determined at 14 days post-injection. The administration of the compound in a single dose modified some of the morphometric parameters of parenchyma (intercalar duct lumen and thickness of the glandular acini) but did not induce tissue inflammatory response, despite the visible presence of polymer waste. This suggests that PLGA microparticles are biocompatible with the parotid tissue, making it possible to use intraglandular controlled drug administration.
dc.language.isoen
dc.subjectDrug delivery
dc.subjectMicroparticles
dc.subjectParotid gland
dc.subjectPLGA
dc.subjectSalivary glands
dc.subjectbiomaterial
dc.subjectdrug carrier
dc.subjectlactic acid
dc.subjectpolyglycolic acid
dc.subjectpolylactic acid polyglycolic acid copolymer
dc.subjectpolylactic acid-polyglycolic acid copolymer
dc.subjectanimal
dc.subjectarticle
dc.subjectchemistry
dc.subjectdrug delivery system
dc.subjectdrug effect
dc.subjectfemale
dc.subjectinjection
dc.subjectmedicinal chemistry
dc.subjectmicroparticles
dc.subjectparotid gland
dc.subjectparticle size
dc.subjectpathology
dc.subjectPLGA
dc.subjectrat
dc.subjectsalivary gland
dc.subjectSprague Dawley rat
dc.subjectdrug delivery
dc.subjectmicroparticles
dc.subjectparotid gland
dc.subjectPLGA
dc.subjectSalivary glands
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectChemistry, Pharmaceutical
dc.subjectDrug Carriers
dc.subjectFemale
dc.subjectInjections
dc.subjectLactic Acid
dc.subjectParotid Gland
dc.subjectParticle Size
dc.subjectPolyglycolic Acid
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.titleIn vivo biocompatibility of the PLGA microparticles in parotid gland
dc.typeArticle


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