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Involvement of JNK1 in Neuronal Polarization During Brain Development

dc.contributor.authorCastro-Torres R.D.
dc.contributor.authorBusquets O.
dc.contributor.authorParcerisas A.
dc.contributor.authorVerdaguer E.
dc.contributor.authorOlloquequi J.
dc.contributor.authorEtchetto M.
dc.contributor.authorBeas-Zarate C.
dc.contributor.authorFolch J.
dc.contributor.authorCamins A.
dc.contributor.authorAuladell C.
dc.date.accessioned2020-09-02T22:14:06Z
dc.date.available2020-09-02T22:14:06Z
dc.date.issued2020
dc.identifier10.3390/cells9081897
dc.identifier.citation9, 8, -
dc.identifier.issn20734409
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3872
dc.descriptionThe c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS.
dc.language.isoen
dc.publisherNLM (Medline)
dc.subjectasymmetric division
dc.subjectDCX
dc.subjectJNK1
dc.subjectMAP1B
dc.subjectmigration
dc.subjectNMDAR
dc.subjectSCG10
dc.subjectsynaptogenesis
dc.subjectWDR62
dc.titleInvolvement of JNK1 in Neuronal Polarization During Brain Development
dc.typeReview


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