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Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies

dc.contributor.authorCafferata E.A.
dc.contributor.authorAlvarez C.
dc.contributor.authorDiaz K.T.
dc.contributor.authorMaureira M.
dc.contributor.authorMonasterio G.
dc.contributor.authorGonzález F.E.
dc.contributor.authorCovarrubias C.
dc.contributor.authorVernal R.
dc.date.accessioned2020-09-02T22:13:45Z
dc.date.available2020-09-02T22:13:45Z
dc.date.issued2019
dc.identifier10.1111/odi.13023
dc.identifier.citation25, 8, 1866-1878
dc.identifier.issn1354523X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3863
dc.descriptionPeriodontitis is an inflammatory disease, in which the host immuno-inflammatory response against the dysbiotic subgingival biofilm leads to the breakdown of periodontal tissues. Most of the available treatments seem to be effective in the short-term; nevertheless, permanent periodical controls and patient compliance compromise long-term success. Different strategies have been proposed for the modulation of the host immune response as potential therapeutic tools to take a better care of most susceptible periodontitis patients, such as drug local delivery approaches. Though, maintaining an effective drug concentration for a prolonged period of time has not been achieved yet. In this context, advanced drug delivery strategies using biodegradable nanocarriers have been proposed to avoid toxicity and frequency-related problems of treatment. The versatility of distinct nanocarriers allows the improvement of their loading and release capabilities and could be potentially used for microbiological control, periodontal regeneration, and/or immunomodulation. In the present review, we revise and discuss the most frequent biodegradable nanocarrier strategies proposed for the treatment of periodontitis, including polylactic-co-glycolic acid (PLGA), chitosan, and silica-derived nanoparticles, and further suggest novel therapeutic strategies. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectbioactive glass
dc.subjectchitosan
dc.subjectnanoparticles
dc.subjectperiodontitis
dc.subjectPLGA
dc.subjectregulatory T lymphocytes
dc.subjectantiinfective agent
dc.subjectchitosan nanoparticle
dc.subjectmesoporous silica nanoparticle
dc.subjectnanocarrier
dc.subjectpolyglactin
dc.subjectantiinfective agent
dc.subjectchitosan
dc.subjectnanoparticle
dc.subjectadaptive immunity
dc.subjectantimicrobial activity
dc.subjectdrug delivery system
dc.subjecteffective concentration
dc.subjecthuman
dc.subjectimmunomodulation
dc.subjectinnate immunity
dc.subjectnonhuman
dc.subjectpatient compliance
dc.subjectperiodontitis
dc.subjectpriority journal
dc.subjectReview
dc.subjecttissue regeneration
dc.subjectchemistry
dc.subjectdrug delivery system
dc.subjectperiodontitis
dc.subjectAnti-Bacterial Agents
dc.subjectAnti-Infective Agents
dc.subjectChitosan
dc.subjectDrug Delivery Systems
dc.subjectHumans
dc.subjectNanoparticles
dc.subjectPeriodontitis
dc.subjectPolylactic Acid-Polyglycolic Acid Copolymer
dc.titleMultifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies
dc.typeReview


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