Mostrar el registro sencillo del ítem

Solar uv radiation-induced dna bipyrimidine photoproducts: Formation and mechanistic insights

dc.contributor.authorCadet J.
dc.contributor.authorGrand A.
dc.contributor.authorDouki T.
dc.date.accessioned2020-09-02T22:13:45Z
dc.date.available2020-09-02T22:13:45Z
dc.date.issued2015
dc.identifier10.1007/128_2014_553
dc.identifier.citation356, , 249-276
dc.identifier.issn03401022
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3862
dc.descriptionThis review chapter presents a critical survey of the main available information on the UVB and UVA bipyrimidine photoproducts which constitute the predominant recipient classes of photo-induced DNA damage. Evidence is provided that UVB irradiation of isolated DNA in aqueous solutions and in cells gives rise to the predominant generation of cis-syn cyclobutane pyrimidine dimers (CPDs) and, to a lesser extent, of pyrimidine (6-4) pyrimidone photoproducts (6-4PPs), the importance of which is strongly primary sequence dependent. A notable change in the photoproduct distribution is observed when DNA either in the dry or in desiccated microorganisms is exposed to UVC or UVB photons with an overwhelming formation of 5-(α-thymidyl)-5,6-dihydrothymidine, also called spore photoproduct (dSP), at the expense of CPDs and 6-4PPs. UVA irradiation of isolated and cellular DNA gives rise predominantly to bipyrimidine photoproducts with the overwhelming formation of thymine-containing cyclobutane pyrimidine dimers at the exclusion of 6-4PPs. UVA photons have been shown to modulate the distribution of UVB dimeric pyrimidine photoproducts by triggering isomerization of the 6-4PPs into related Dewar valence isomers. Mechanistic aspects of the formation of bipyrimidine photoproducts are discussed in the light of recent photophysical and theoretical studies. © Springer-Verlag Berlin Heidelberg 2014.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subjectCellular DNA photodamage
dc.subjectCyclobutane pyrimidine dimmers
dc.subjectDewar valence isomers
dc.subjectPyrimidine (6-4) pyrimidone photoproducts
dc.subjectSpore photoproduct
dc.subjectDNA
dc.subjectguanine quadruplex
dc.subjectpyrimidine dimer
dc.subjectsolution and solubility
dc.subjectadverse effects
dc.subjectarchaeon
dc.subjectBacteria
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectDNA damage
dc.subjectgenetics
dc.subjecthuman
dc.subjectisolation and purification
dc.subjectmetabolism
dc.subjectradiation response
dc.subjectskin
dc.subjectsolution and solubility
dc.subjectstereoisomerism
dc.subjectsunlight
dc.subjectultraviolet radiation
dc.subjectArchaea
dc.subjectBacteria
dc.subjectDNA
dc.subjectDNA Damage
dc.subjectG-Quadruplexes
dc.subjectHumans
dc.subjectMolecular Structure
dc.subjectPyrimidine Dimers
dc.subjectSkin
dc.subjectSolutions
dc.subjectStereoisomerism
dc.subjectSunlight
dc.subjectUltraviolet Rays
dc.titleSolar uv radiation-induced dna bipyrimidine photoproducts: Formation and mechanistic insights
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84927515918.pdf
Tamaño:
3.226Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem