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Cytotoxic and apoptotic effects of leptocarpin, a plant-derived sesquiterpene lactone, on human cancer cell lines

dc.contributor.authorBosio C.
dc.contributor.authorTomasoni G.
dc.contributor.authorMartínez R.
dc.contributor.authorOlea A.F.
dc.contributor.authorCarrasco H.
dc.contributor.authorVillena J.
dc.date.accessioned2020-09-02T22:13:45Z
dc.date.available2020-09-02T22:13:45Z
dc.date.issued2015
dc.identifier10.1016/j.cbi.2015.11.006
dc.identifier.citation242, , 415-421
dc.identifier.issn00092797
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3859
dc.descriptionSesquiterpene lactones have attracted much attention in drug research because they present a series of biological activities such as anticancer, antifungal, anti-inflammatory, antimicrobial and antioxidant. Leptocarpin (LTC) is a sesquiterpene lactone isolated from a native Chilean plant, Leptocarpha rivularis, which has been widely used in traditional medicine by Mapuche people. Previous work has demonstrated that LTC decreases cell viability of cancer cell lines. In this contribution, we analyze the mechanism of LTC cytotoxicity on different cancer cell lines. The results show that in all cases LTC induces an apoptotic process and inhibition of NF-κB. Apoptosis has been confirmed by observing condensation of chromatin, nuclear fragmentation, release of cytochrome c into the cytosol, and increasing of caspase-3 activity. It has also been found that LTC is an effective inhibitor of NF-κB, which suggests that leptocarpin-induced cytotoxicity involves in some degree the inhibition of NF-κB signaling pathway. The concentration at which LTC inhibits NF-κB activity to the control level is similar or even lower than that found for parthenolide and others sesquiterpene lactones. These results indicate that leptocarpine is a very interesting molecule that could be considered as therapeutic agent for cancer treatment. © 2015 Elsevier Ireland Ltd.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectApoptosis
dc.subjectCancer cell lines
dc.subjectCytotoxicity
dc.subjectFactor NF-κB
dc.subjectLeptocarpin
dc.subjectSesquiterpene lactones
dc.subjectapoptosis inducing factor
dc.subjectcaspase 3
dc.subjectcytochrome c
dc.subjectcytotoxic agent
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectleptocarpin
dc.subjectunclassified drug
dc.subjectantineoplastic agent
dc.subjectcytochrome c
dc.subjectleptocarpin
dc.subjectsesquiterpene
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcancer cell line
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectdrug cytotoxicity
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectdrug structure
dc.subjectenzyme activity
dc.subjectflow cytometry
dc.subjecthuman
dc.subjecthuman cell
dc.subjectIC50
dc.subjectmale
dc.subjectprotein secretion
dc.subjectsignal transduction
dc.subjectapoptosis
dc.subjectAsteraceae
dc.subjectchemistry
dc.subjectcytosol
dc.subjectdrug effects
dc.subjectsecretion (process)
dc.subjecttumor cell line
dc.subjectAntineoplastic Agents
dc.subjectApoptosis
dc.subjectAsteraceae
dc.subjectCell Line, Tumor
dc.subjectCytochromes c
dc.subjectCytosol
dc.subjectHumans
dc.subjectSesquiterpenes
dc.titleCytotoxic and apoptotic effects of leptocarpin, a plant-derived sesquiterpene lactone, on human cancer cell lines
dc.typeArticle


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