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PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult

dc.contributor.authorCabezas R.
dc.contributor.authorVega-Vela N.E.
dc.contributor.authorGonzález-Sanmiguel J.
dc.contributor.authorGonzález J.
dc.contributor.authorEsquinas P.
dc.contributor.authorEcheverria V.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:13:43Z
dc.date.available2020-09-02T22:13:43Z
dc.date.issued2018
dc.identifier10.1007/s12035-017-0567-6
dc.identifier.citation55, 4, 3085-3095
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3853
dc.descriptionPlatelet-derived growth factor, subtype BB (PDGF-BB) is a mitogenic growth factor produced in different cell types such as platelets, fibroblasts, neurons, and astrocytes. Previous reports have shown that different PDGF isoforms exert a neuroprotective effect in neurons and astrocytes against multiple degenerative insults. Previously, we showed that pretreatment with PDGF-BB for 24 h increased cell viability, preserved nuclear morphology and mitochondrial membrane potential following stimulation with rotenone, and reduced free radical production nearly to control conditions. In the present study, we explored the potential mechanisms associated with PDGF-BB protection against oxidative damage. Our results showed that PDGF-BB protected astrocytic cells through multiple responses, including decrease in the expression of cytoskeleton proteins, attenuated free radicals (reactive oxygen species (ROS)) production, preservation of mitochondrial ultrastructure, and improved expression of neuroglobin (Ngb1). In summary, these findings point out that PDGF-BB protects astrocytic cells by a reduction in ROS production and activation of antioxidant mechanisms. © 2017, Springer Science+Business Media New York.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAstrocytes
dc.subjectMitochondria
dc.subjectNeuroglobin
dc.subjectPDGF-BB
dc.subjectReactive oxygen species
dc.subjectRotenone
dc.subjectcytoskeleton protein
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectneuroglobin
dc.subjectplatelet derived growth factor BB
dc.subjectreactive oxygen metabolite
dc.subjectrotenone
dc.subjectbiological marker
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectneuroglobin
dc.subjectphosphatidylinositol 3 kinase
dc.subjectplatelet derived growth factor
dc.subjectprotein kinase B
dc.subjectreactive oxygen metabolite
dc.subjectrotenone
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectastrocyte
dc.subjectcell protection
dc.subjectcell structure
dc.subjectcell ultrastructure
dc.subjectcontrolled study
dc.subjectmitochondrion
dc.subjectoxidative stress
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectupregulation
dc.subjectastrocyte
dc.subjectcytoskeleton
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmetabolism
dc.subjectmitochondrion
dc.subjectsignal transduction
dc.subjecttumor cell line
dc.subjectultrastructure
dc.subjectupregulation
dc.subjectAstrocytes
dc.subjectBiomarkers
dc.subjectCell Line, Tumor
dc.subjectCytoskeleton
dc.subjectHumans
dc.subjectMitochondria
dc.subjectNeuroglobin
dc.subjectNF-kappa B
dc.subjectPhosphatidylinositol 3-Kinases
dc.subjectPlatelet-Derived Growth Factor
dc.subjectProto-Oncogene Proteins c-akt
dc.subjectReactive Oxygen Species
dc.subjectRotenone
dc.subjectSignal Transduction
dc.subjectUp-Regulation
dc.titlePDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult
dc.typeArticle


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