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Growth factors and astrocytes metabolism: Possible roles for platelet derived growth factor

dc.contributor.authorCabezas R.
dc.contributor.authorAvila-Rodriguez M.
dc.contributor.authorVega-Vela N.E.
dc.contributor.authorEcheverria V.
dc.contributor.authorGonzález J.
dc.contributor.authorHidalgo O.A.
dc.contributor.authorSantos A.B.
dc.contributor.authorAliev G.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:13:43Z
dc.date.available2020-09-02T22:13:43Z
dc.date.issued2016
dc.identifier10.2174/1573406411666151019120444
dc.identifier.citation12, 3, 204-210
dc.identifier.issn15734064
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3850
dc.descriptionAstrocytes exert multiple functions in the brain such as the development of blood-brain barrier characteristics, the promotion of neurovascular coupling, attraction of cells through the release of chemokines, clearance of toxic substances and generation of antioxidant molecules and growth factors. In this aspect, astrocytes secrete several growth factors (BDNF, GDNF, NGF, and others) that are fundamental for cell viability, oxidant protection, genetic expression and modulation of metabolic functions. The platelet derived growth factor (PDGF), which is expressed by many SNC cells, including astrocytes, is an important molecule that has shown neuroprotective potential, improvement of wound healing, regulation of calcium metabolism and mitochondrial function. Here we explore some of these astrocyte-driven functions of growth factors and their possible therapeutic uses in the context of neurodegeneration. © 2016 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAstrocyte
dc.subjectGrowth factors
dc.subjectMetabolism
dc.subjectMitochondria
dc.subjectNeuroprotection
dc.subjectPlatelet derived growth factor
dc.subjectadenosine triphosphatase (potassium sodium)
dc.subjectbrain derived neurotrophic factor
dc.subjectglial cell line derived neurotrophic factor
dc.subjectgrowth factor
dc.subjectnerve growth factor
dc.subjectneuroprotective agent
dc.subjectneurotrophic factor
dc.subjectperoxisome proliferator activated receptor gamma
dc.subjectplatelet derived growth factor
dc.subjectplatelet derived growth factor BB
dc.subjectscatter factor
dc.subjectsomatomedin
dc.subjectvasculotropin
dc.subjectvasculotropin B
dc.subjectwound healing promoting agent
dc.subjectplatelet derived growth factor
dc.subjectArticle
dc.subjectastrocyte
dc.subjectblood brain barrier
dc.subjectcalcium metabolism
dc.subjectcell metabolism
dc.subjectcell protection
dc.subjectcell viability
dc.subjectdopaminergic nerve cell
dc.subjectdrug activity
dc.subjectdrug delivery system
dc.subjectgene expression
dc.subjectglial precursor cell
dc.subjecthuman
dc.subjectmitochondrion
dc.subjectnerve degeneration
dc.subjectneuroprotection
dc.subjectoxidation
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectwound healing
dc.subjectanimal
dc.subjectastrocyte
dc.subjectmetabolism
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectHumans
dc.subjectPlatelet-Derived Growth Factor
dc.titleGrowth factors and astrocytes metabolism: Possible roles for platelet derived growth factor
dc.typeArticle


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