Mostrar el registro sencillo del ítem

Preference for high-fat diet is developed by young Swiss CD1 mice after short-term feeding and is prevented by NMDA receptor antagonists

dc.contributor.authorButtigieg A.
dc.contributor.authorFlores O.
dc.contributor.authorHernández A.
dc.contributor.authorSáez-Briones P.
dc.contributor.authorBurgos H.
dc.contributor.authorMorgan C.
dc.date.accessioned2020-09-02T22:13:38Z
dc.date.available2020-09-02T22:13:38Z
dc.date.issued2014
dc.identifier10.1016/j.nlm.2013.10.018
dc.identifier.citation107, , 13-18
dc.identifier.issn10747427
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3821
dc.descriptionObesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in time to specific metabolic effects. Mice that were weaned 21. days postpartum and fed a chow diet for one week were afterward subjected to a diet preference test for 5. days, exposed to both a regular diet (RD) and HFD. We found that mice did not show any preferences. In a second experiment, two groups of mice that were weaned 21. days postpartum and subjected to a chow diet for one week were fed either RD or HFD for 18. days, and a diet preference test was performed for 5. days. After this short-term consumption of HFD, mice preferred HFD, while mice subjected to RD did not show any preference. Importantly, no differences in blood glucose levels were found between the groups prior to and after the experiments. The results support our hypothesis that the preference for HFD is not a spontaneous behavior in CD1 mice, but it can be observed after short-term consumption; additionally, this preference develops before metabolic effects appear. Finally, this preference for HFD could not be observed when the mice were i.p. injected daily with low doses of the NMDA receptor antagonists, ketamine, ifenprodil or MK-801 during the HFD feeding period. These data suggest that acquisition of dietary preference for HFD is a NMDA receptor-dependent learning process. © 2013 Elsevier Inc.
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectDietary preference
dc.subjectFeeding behavior
dc.subjectHigh-fat diet
dc.subjectObesity
dc.subjectdizocilpine
dc.subjectglucose
dc.subjectifenprodil
dc.subjectketamine
dc.subjectn methyl dextro aspartic acid receptor blocking agent
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdiet preference test
dc.subjectexperimental test
dc.subjectfeeding behavior
dc.subjectglucose blood level
dc.subjectlipid diet
dc.subjectlow drug dose
dc.subjectmale
dc.subjectmetabolism
dc.subjectmouse
dc.subjectnonhuman
dc.subjectDietary preference
dc.subjectFeeding behavior
dc.subjectHFD
dc.subjecthigh-fat diet
dc.subjectHigh-fat diet
dc.subjectN-methyl-D-Aspartate
dc.subjectNMDA
dc.subjectObesity
dc.subjectPBS
dc.subjectphosphate buffer saline
dc.subjectRD
dc.subjectregular diet
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectDiet, High-Fat
dc.subjectDizocilpine Maleate
dc.subjectExcitatory Amino Acid Antagonists
dc.subjectFood Preferences
dc.subjectKetamine
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Strains
dc.subjectPiperidines
dc.subjectReceptors, N-Methyl-D-Aspartate
dc.titlePreference for high-fat diet is developed by young Swiss CD1 mice after short-term feeding and is prevented by NMDA receptor antagonists
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84888268636.pdf
Tamaño:
3.562Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem