Mostrar el registro sencillo del ítem

Melatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arsenite [Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio]

dc.contributor.authorBustos-Obregón E.
dc.contributor.authorPoblete D.
dc.contributor.authorCatriao R.
dc.contributor.authordel Sol M.
dc.contributor.authorFernandes F.H.
dc.date.accessioned2020-09-02T22:13:38Z
dc.date.available2020-09-02T22:13:38Z
dc.date.issued2013
dc.identifier10.4067/S0717-95022013000400017
dc.identifier.citation31, 4, 1251-1256
dc.identifier.issn07179367
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3819
dc.descriptionWe evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days.
dc.language.isoen
dc.language.isoes
dc.subjectArsenic
dc.subjectDNA stability
dc.subjectMelatonin
dc.subjectMouse
dc.subjectSperm
dc.titleMelatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arsenite [Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio]
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84894276180.pdf
Tamaño:
2.430Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem