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New ABCC2 RS3740066 and RS2273697 polymorphisms identified in a healthy colombian cohort

dc.contributor.authorBustos-Cruz R.H.
dc.contributor.authorMartínez L.R.
dc.contributor.authorGarcía J.C.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSuárez F.
dc.date.accessioned2020-09-02T22:13:38Z
dc.date.available2020-09-02T22:13:38Z
dc.date.issued2018
dc.identifier10.3390/pharmaceutics10030093
dc.identifier.citation10, 3, -
dc.identifier.issn19994923
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3818
dc.descriptionMultidrug resistance-associated proteins (MRP) 1 and 2 belong to the ABC (ATP-Binding Cassette) transporters. These transport proteins are involved in the removal of various drugs and xenobiotics, as well as in multiple physiological, pathological, and pharmacological processes. There is a strong correlation between different polymorphisms and their clinical implication in resistance to antiepileptic drugs, anticancer, and anti-infective agents. In our study, we evaluated exon regions of MRP1 (ABCC1)/MRP2 (ABCC2) in a Colombian cohort of healthy subjects to determine single nucleotide polymorphisms (SNPs) and to determine the allelic and genomic frequency. Results showed there are SNPs in our population that have been previously reported for both MRP1/ABCC1 (rs200647436, rs200624910, rs150214567) and MRP2/ABCC2 (rs2273697, rs3740066, rs142573385, rs17216212). Additionally, 13 new SNPs were identified. Evidence also shows a significant clinical correlation for polymorphisms rs3740066 and rs2273697 in the transport of multiple drugs, which suggests a genetic variability in regards to that reported in other populations. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectATP-Binding-cassette (ABC)
dc.subjectDrug resistance
dc.subjectGenetic variability
dc.subjectMRP1 and MRP2
dc.subjectPolymorphisms
dc.subjectgenomic DNA
dc.subjectmultidrug resistance associated protein 1
dc.subjectmultidrug resistance associated protein 2
dc.subjectABCC1 gene
dc.subjectABCC2 gene
dc.subjectamplicon
dc.subjectArticle
dc.subjectColombian
dc.subjectDNA sequence
dc.subjectexon
dc.subjectfemale
dc.subjectgene amplification
dc.subjectgene frequency
dc.subjecthuman
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectsequence analysis
dc.subjectsingle nucleotide polymorphism
dc.titleNew ABCC2 RS3740066 and RS2273697 polymorphisms identified in a healthy colombian cohort
dc.typeArticle


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