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Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats

dc.contributor.authorBurgos H.
dc.contributor.authorHernández A.
dc.contributor.authorConstandil L.
dc.contributor.authorRíos M.
dc.contributor.authorFlores O.
dc.contributor.authorPuentes G.
dc.contributor.authorHernández K.
dc.contributor.authorMorgan C.
dc.contributor.authorValladares L.
dc.contributor.authorCastillo A.
dc.contributor.authorCofre C.
dc.contributor.authorMilla L.A.
dc.contributor.authorSáez-Briones P.
dc.contributor.authorBarra R.
dc.date.accessioned2020-09-02T22:13:35Z
dc.date.available2020-09-02T22:13:35Z
dc.date.issued2019
dc.identifier10.1016/j.bbr.2019.02.001
dc.identifier.citation363, , 182-190
dc.identifier.issn01664328
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3805
dc.descriptionModerate reduction of dietary protein (from 25% to 8% casein) in pregnant rats, calorically compensated by carbohydrates, gives rise to ‘hidden prenatal malnutrition’ (HPM) in the offspring since it does not alter body and brain weights of pups at birth. However, this dietary treatment leads to decreased β-adrenoceptor signaling and brain derived neurotrophic factor (BDNF) levels in the pup’ brain, altogether with defective cortical long-term potentiation (LTP) and lowered visuospatial memory performance. Since early postnatal environmental enrichment (EE) has been shown to exert plastic effects on the developing brain and neuroprotection both on cognition and on structural properties of the neocortex, in the present study we addressed the question of whether early postnatal EE during the lactation period could exert compensatory changes in the expression of ®-adrenergic receptors and BDNF in the neocortex of HPM rats, and if these effects are associated with an improvement or even a restore of both neocortical LTP in vivo and cognitive performance induced by HPM. The results obtained show that EE restored β-adrenoceptor density, BDNF expression and the ability to support LTP at prefrontal and occipital cortices of HPM rats. Besides, EE improved learning performance in visuospatial and operant conditioning tasks. The latter support the notion that adequate maternal protein nutrition during pregnancy is required for proper brain development and function. Further, the results highlight the role of environmental enrichment during early postnatal life in increasing later brain plasticity and exerting neuroprotection against brain deficits induced by prenatal malnutrition. © 2019
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectBrain-derived neurotrophic factor
dc.subjectLearning
dc.subjectLong-term potentiation
dc.subjectNeocortex
dc.subjectPrenatal protein malnutrition
dc.subjectβ-Adrenoceptor
dc.subjectbeta adrenergic receptor
dc.subjectbrain derived neurotrophic factor
dc.subjectbeta adrenergic receptor
dc.subjectbrain derived neurotrophic factor
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrain cortex
dc.subjectbrain development
dc.subjectbrain function
dc.subjectcognition
dc.subjectcontrolled study
dc.subjectenvironmental enrichment
dc.subjectfemale
dc.subjectfetal malnutrition
dc.subjectgene expression
dc.subjectin vivo study
dc.subjectinstrumental conditioning
dc.subjectlactation
dc.subjectlearning
dc.subjectlong term potentiation
dc.subjectmaternal nutrition
dc.subjectmemory
dc.subjectneocortex
dc.subjectnerve cell plasticity
dc.subjectneurochemistry
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectoccipital cortex
dc.subjectperinatal period
dc.subjectprefrontal cortex
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectprotein intake
dc.subjectrat
dc.subjectreceptor density
dc.subjectspatial memory test
dc.subjectyoung adult
dc.subjectanimal
dc.subjectbrain cortex
dc.subjectlearning
dc.subjectmale
dc.subjectmalnutrition
dc.subjectmetabolism
dc.subjectnerve cell plasticity
dc.subjectnewborn
dc.subjectoccipital lobe
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpostnatal care
dc.subjectprenatal exposure
dc.subjectprocedures
dc.subjectpsychology
dc.subjectSprague Dawley rat
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectCerebral Cortex
dc.subjectCognition
dc.subjectFemale
dc.subjectLearning
dc.subjectLong-Term Potentiation
dc.subjectMale
dc.subjectMalnutrition
dc.subjectMemory
dc.subjectNeocortex
dc.subjectNeuronal Plasticity
dc.subjectOccipital Lobe
dc.subjectPostnatal Care
dc.subjectPregnancy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReceptors, Adrenergic, beta
dc.titleEarly postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats
dc.typeArticle


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