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Methylphenidate has long-lasting metaplastic effects in the prefrontal cortex of adolescent rats
dc.contributor.author | Burgos H. | |
dc.contributor.author | Cofré C. | |
dc.contributor.author | Hernández A. | |
dc.contributor.author | Sáez-Briones P. | |
dc.contributor.author | Agurto R. | |
dc.contributor.author | Castillo A. | |
dc.contributor.author | Morales B. | |
dc.contributor.author | Zeise M.L. | |
dc.date.accessioned | 2020-09-02T22:13:35Z | |
dc.date.available | 2020-09-02T22:13:35Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1016/j.bbr.2015.05.009 | |
dc.identifier.citation | 291, , 112-117 | |
dc.identifier.issn | 01664328 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/3803 | |
dc.description | Methylphenidate (MPH) is widely used as a "nootropic" agent and in the treatment of disorders of attention, and has been shown to modulate synaptic plasticity in vitro. Here we present in vivo evidence that this MPH-induced metaplasticity can last long after the end of treatment. MPH (0, 0.2, 1 and 5. mg/kg) was administered daily to male rats from postnatal day 42 for 15 days. The animals were tested daily in a radial maze. Long-term potentiation (LTP), a marker of neural plasticity, was induced in vivo in the prefrontal cortex after 2-3. h, 15-18 days or 5 months without treatment. The behavioral performance of the 1. mg/kg group improved, while that of animals that had received 5. mg/kg deteriorated. In the 1 and 5. mg/kg groups LTP induced 2-3. h after the last MPH treatment was twice as large as in the controls. Further, 15-18 days after the last MPH administration, in groups receiving 1 and 5. mg/kg, LTP was about fourfold higher than in controls. However, 5 months later, LTP in the 1. mg/kg group was similar to controls and in the 5. mg/kg group LTP could not be induced at all. No significant changes of LTP were seen in the low-dose group of animals (0.2. mg/kg). Thus, firstly, doses of MPH that improve learning coincide approximately with those that augment LTP. Secondly, MPH-induced increases in LTP can last for several weeks, but these may disappear over longer periods or deteriorate at high doses. © 2015 Elsevier B.V. | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.subject | Long-term potentiation | |
dc.subject | Metaplasticity | |
dc.subject | Methylphenidate | |
dc.subject | Prefrontal cortex | |
dc.subject | methylphenidate | |
dc.subject | central stimulant agent | |
dc.subject | methylphenidate | |
dc.subject | nootropic agent | |
dc.subject | animal experiment | |
dc.subject | Article | |
dc.subject | controlled study | |
dc.subject | experimental behavioral test | |
dc.subject | in vivo study | |
dc.subject | learning | |
dc.subject | long term potentiation | |
dc.subject | male | |
dc.subject | mental performance | |
dc.subject | metaplasticity | |
dc.subject | nerve cell plasticity | |
dc.subject | nonhuman | |
dc.subject | perinatal period | |
dc.subject | prefrontal cortex | |
dc.subject | priority journal | |
dc.subject | radial arm maze test | |
dc.subject | rat | |
dc.subject | task performance | |
dc.subject | animal | |
dc.subject | dose response | |
dc.subject | drug effects | |
dc.subject | growth, development and aging | |
dc.subject | maze test | |
dc.subject | microelectrode | |
dc.subject | physiology | |
dc.subject | prefrontal cortex | |
dc.subject | Sprague Dawley rat | |
dc.subject | Animals | |
dc.subject | Central Nervous System Stimulants | |
dc.subject | Dose-Response Relationship, Drug | |
dc.subject | Long-Term Potentiation | |
dc.subject | Male | |
dc.subject | Maze Learning | |
dc.subject | Methylphenidate | |
dc.subject | Microelectrodes | |
dc.subject | Nootropic Agents | |
dc.subject | Prefrontal Cortex | |
dc.subject | Rats, Sprague-Dawley | |
dc.title | Methylphenidate has long-lasting metaplastic effects in the prefrontal cortex of adolescent rats | |
dc.type | Article |