Mostrar el registro sencillo del ítem

Manganese superoxide dismutase and oxidative stress modulation

dc.contributor.authorBresciani G.
dc.contributor.authorda Cruz I.B.M.
dc.contributor.authorGonzález-Gallego J.
dc.date.accessioned2020-09-02T22:13:33Z
dc.date.available2020-09-02T22:13:33Z
dc.date.issued2015
dc.identifier10.1016/bs.acc.2014.11.001
dc.identifier.citation68, , 87-130
dc.identifier.issn00652423
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3787
dc.descriptionOxidative stress is characterized by imbalanced reactive oxygen species (ROS) production and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system relies on molecules to directly quench ROS and the enzymatic system is composed of specific enzymes that detoxify ROS. Among the latter, the superoxide dismutase (SOD) family is important in oxidative stress modulation. Of these, manganese-dependent SOD (MnSOD) plays a major role due to its mitochondrial location, i.e., the main site of superoxide (O2•-) production. As such, extensive research has focused on its capacity to modulate oxidative stress. Early data demonstrated the relevance of MnSOD as an O2•- scavenger. More recent research has, however, identified a prominent role for MnSOD in carcinogenesis. In addition, SOD downregulation appears associated with health risk in heart and brain. A single nucleotide polymorphism which alters the mitochondria signaling sequence for the cytosolic MnSOD form has been identified. Transport into the mitochondria was differentially affected by allelic presence and a new chapter in MnSOD research thus begun. As a result, an ever-increasing number of diseases appear associated with this allelic variation including metabolic and cardiovascular disease. Although diet and exercise upregulate MnSOD, the relationship between environmental and genetic factors remains unclear. © 2015 Elsevier Inc.
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectDiseases
dc.subjectEnvironmental factors
dc.subjectMnSOD
dc.subjectOxidative stress
dc.subjectSNP
dc.subjectTranslational and posttranslational modulation
dc.subjectreactive oxygen metabolite
dc.subjectsuperoxide dismutase
dc.subjectexercise
dc.subjectgenetics
dc.subjecthuman
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectphysiology
dc.subjectsingle nucleotide polymorphism
dc.subjectExercise
dc.subjectgenetics
dc.subjectHumans
dc.subjectmetabolism
dc.subjectOxidative Stress
dc.subjectphysiology
dc.subjectPolymorphism, Single Nucleotide
dc.subjectReactive Oxygen Species
dc.subjectSuperoxide Dismutase
dc.titleManganese superoxide dismutase and oxidative stress modulation
dc.typeBook Chapter


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84964277241.pdf
Tamaño:
2.851Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem