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Functional constraints in the evolution of brain circuits

dc.contributor.authorBosman C.A.
dc.contributor.authorAboitiz F.
dc.date.accessioned2020-09-02T22:13:31Z
dc.date.available2020-09-02T22:13:31Z
dc.date.issued2015
dc.identifier10.3389/fnins.2015.00303
dc.identifier.citation9, SEP, -
dc.identifier.issn16624548
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3771
dc.descriptionRegardless of major anatomical and neurodevelopmental differences, the vertebrate isocortex shows a remarkably well-conserved organization. In the isocortex, reciprocal connections between excitatory and inhibitory neurons are distributed across multiple layers, encompassing modular, dynamical and recurrent functional networks during information processing. These dynamical brain networks are often organized in neuronal assemblies interacting through rhythmic phase relationships. Accordingly, these oscillatory interactions are observed across multiple brain scale levels, and they are associated with several sensory, motor, and cognitive processes. Most notably, oscillatory interactions are also found in the complete spectrum of vertebrates. Yet, it is unknown why this functional organization is so well conserved in evolution. In this perspective, we propose some ideas about how functional requirements of the isocortex can account for the evolutionary stability observed in microcircuits across vertebrates. We argue that isocortex architectures represent canonical microcircuits resulting from: (i) the early selection of neuronal architectures based on the oscillatory excitatory-inhibitory balance, which lead to the implementation of compartmentalized oscillations and (ii) the subsequent emergence of inferential coding strategies (predictive coding), which are able to expand computational capacities. We also argue that these functional constraints may be the result of several advantages that oscillatory activity contributes to brain network processes, such as information transmission and code reliability. In this manner, similarities in mesoscale brain circuitry and input-output organization between different vertebrate groups may reflect evolutionary constraints imposed by these functional requirements, which may or may not be traceable to a common ancestor. © 2015 Bosman and Aboitiz.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectCanonical microcircuits
dc.subjectCortical evolution
dc.subjectCortical neurodevelopment
dc.subjectNeuronal oscillations
dc.subjectPredictive coding
dc.subjecttranscription factor ER81
dc.subjectalpha rhythm
dc.subjectarousal
dc.subjectArticle
dc.subjectattention
dc.subjectbeta rhythm
dc.subjectbrain development
dc.subjectconnectome
dc.subjectgamma rhythm
dc.subjecthippocampus theta rhythm
dc.subjectnegative feedback
dc.subjectneocortex
dc.subjectneurotransmission
dc.subjectnoise
dc.subjectnonhuman
dc.subjectoscillation
dc.subjectpositive feedback
dc.subjectprotein expression
dc.subjectspatial behavior
dc.subjectspike wave
dc.subjectstimulus response
dc.subjectsynaptic potential
dc.subjectvisual discrimination
dc.titleFunctional constraints in the evolution of brain circuits
dc.typeArticle


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